The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol

Hiv Nukes

Here's a taste of what has to offer on this topic:
Project Inform

Nukes? Or No Nukes?

While specific drugs have fallen in and out of favor, the basic structure of anti-HIV therapy -- called HAART -- has changed very little since the late 1990s. Almost all regimens include one highly potent drug -- either a boosted protease inhibitor... Read more »
Seattle Treatment Education Project

Know Your HIV Drugs: NRTIs (The Nukes)

In recent years the drug choices available to people with HIV have increased substantially. There are currently 16 approved antiviral drugs for HIV and these drugs are usually used in combinations of three or more to create an effective antiviral... Read more »

Initial HIV Treatment With a 2-Drug, Nuke-Sparing Regimen Falls Short

For many years, we've wondered about the long-term safety of nucleoside/tide reverse transcriptase inhibitors (NRTIs). Our sometimes-lethal experiences with dideoxynucleosides cemented this sentiment, one that lingers today, even with far better... Read more »
Ask the Experts

nukes vs non nukes

I work for an ASO and I I get question all the time and I need a simple answers. Can you please tell me the differnce between a nukes and non-nukes and must PHA's take at least one class of the meds?Steve...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your post.There is a wealth of information about these medications here at In brief, nukes are nucleoside reverse transcriptase (RT) inhibitors(include AZT,d4T, ddI, 3TC, FTC, abacavir and with a minor caveat, tenofovir).... Read more »

nukes non-nukes and tides

Can you explain, in simple terms, the differences between nukes, non-nukes, and nucleotide reverse transcriptase inhibitors and the mechanisms they use to stop viral replication?...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
HIV reverse transcriptase is the viral enzyme that is largely responsible for replication of the viral genes. There are three different classes of medications that inhibit the HIV reverse transcriptase.Nucleoside RT inhibitors (nukes) are the... Read more »

Switching nukes and PI to nukes and non nuke

Dear Dr. Pierone:I live in Mexico and I was detected on December 2000, viral load around 330,000 and CD4 absolute number 275. I started with combivir and rescriptor. Approximately, one year later I have to quit this regimen because of intolerance...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Hello, and thanks for posting. The data are best for Truvada and Sustiva. A number of studies have demonstrated the superiority of Viread (in Truvada) over Zerit so a two agent switch makes sense. I agree with your doctor that changing from Viracept... Read more »

wheres the nuke

Nelsoni see pts can access dtg and ibalizumab soonwhat happened to the new nuke from oz and when can we access?...
Nelson Vergel, B.S.Ch.E., M.B.A.

Response from Nelson Vergel, B.S.Ch.E., M.B.A.

Program for Wellness Restoration
This new nucleoside is being developed by Avexa. They are now looking for a commercial partner to get funding to market the drug after approval. Their last press release on apricitabine is here:<a... Read more »
Connect With Others

Traveling with HIV meds

Posted by Anonymous, 3 Replies
Does anyone have any information on traveling to non-democratic countries with HIV meds in your carry-on? And not being allowed in the country?

I went to Syria earlier this year and rather than take my meds, I took a 2 week drug holiday from my... Read more »


Posted by JOHN_IN_LONDON, 1 Reply
Newbie Trap

Celebrated aids doc Brian Gazzard made headlines earlier this year when he kicked off treatment-conservative Britain's first-ever program to give HAART -- with a nuke or non-nuke combo -- to folks brand-newly HIV positive. By treating... Read more »

Irans Breakthrough expected to be announced soon??

Posted by Anonymous, 2 Replies
Have you heard about it?

Iran's Health Minister to unveil breakthrough in AIDS cure

Tehran, Sept 5, IRNA-Iran's Minister of Health and Medical Education Kamran Baqeri Lankarani will unveil a breakthrough achieved by Iranian scientists to cure the... Read more »