Hiv Molecules Stopped By Protease Inhibitors

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Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...

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New Treatment? -- OK to Stop Protease Inhibitor

My Doctor told me to permanently stop my protease inhibitor, I have been on Viracept 1250MG, Zerit 40MB, and Epivir 150MG, all twice daily for 3 years. My CD4 is 1056 and my viral load is undetectable, less than 50. My doctor wants me to take DDI...

Response from Kathleen E. Squires, M.D.

University of Southern California's Keck School of Medicine

Your physician clearly knows the specifics of the course of your HIV infection; it is difficult to try and second-guess. In general, I would not advocate discontinuing such a critical part of a combination regimen without substituting something... Read more »

Protease Inhibitors and Living with HIV/AIDS

Just wondering, is there a train of thought that protease inhibitors may ultimately prevent the possibility of AIDS occuring and basically have people living with HIV for an entire lifetime? Upon initially beginning treatment for hiv is it possible...

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program

Thank you for your questions.When it comes to the protease inhibitors and other antiviral therapies, there is good news and bad news.The good news:1) Treatments have been shown to significantly improve the quantity of a persons life. People taking... Read more »

cryptococcal meningitis Resistant to Protease Inhibitors

What would you advise a patient with CD4s of 8, a Viral Load over 100,000, off therapy for six months because of wasting that may have been caused by meds?weight returned from about 129lbs. to 160lb after stopping Crixivan, Kaletra, Combivir,...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Clearly a tough situation. Maximizing nutrition, maintain good body weight (check testosterone levels),prevention of other opportunistic infections, aggressive use of amphotericin--those treatments can often maintain a person's health. There... Read more »

protease inhibitors should they be avoided?

Dr. Wohl, My question deals with reading over an article from poz magazine this month that questions the effectiveness of protease inhibitors? In the article it becomes clear that protease inhibitors can be the result of many vast side effects and...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

Hi Fred- I have not yet had a chance to pick up the Sept issue but I think we have to be careful about damning a whole class of HIV drugs - especially when 90% of those with HIV infection on the planet are literally dying to have access to these... Read more »

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Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

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