Hiv Integrase Structure

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Other Antiretroviral Drugs in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Integrase Inhibitors After HIV's genetic code is changed from a single strand to a double strand by the reverse transcriptase enzyme, it gets inserted (integrated) into the genetic code of the infected cell. Then the HIV genetic code gets "read," producing new viruses. Scientists hope that integration will be another point in the HIV life...

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integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

ls isentress integrase inhibitors the future for hiv meds ???

Hi Dr Henry,l have been taking different hiv meds for the past 8 years, and its not much fun with the side effects of the meds, l am reading about isentress integtase inhibitors and would like to know your opinion, is this the new step in hiv...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Raltegravir is a promising new HIV treatment known as an integrase inhibitor. It has mostly been used in patients with resistant virus in complex regimens where it has performed well. It has to be taken twice a day. So far it appears well tolerated... Read more »

Integrase Inhibitor

Dr. Young, I am very interested to hear your thoughts on Integrase Inhibitors. -Do you think they will be successful in developing one? -Do you think it can be potentially used as a monotherapy?-Generally what are your thoughts?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your questions.Inhibitors of HIV integrase have been under investigation for some time, though none are currently in advanced clinical trials. There have been a couple of aborted candidate compounds, one from Merck, another from... Read more »

How is s-1360 Integrase Illustrating in Test Results?

Dr. Young,S-1360 Integrase, Yes or No, or possibly?Newman...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Developement of S-1360, an experimental HIV integrase inhibitor has been terminated, because the medication is very poorly absorbed in the human gastrointestinal tract. BYps-- please, only post your question once, not ten times.... Read more »

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Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Today's LA Times Article - Integrase Inhibitors

Posted by Anonymous

Very hopeful! (Despite the sad title.)

http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »

HIV 1 HIV 2

Posted by Anonymous, 1 Reply

Ok I had fellatio performed by a stripper with a condom on. Afterwards I noticed at the base of my penis that it was a little irritated and red around a bump, i guess turned out to be HPV. It was not covered by the condom.
It was 6 weeks later that... Read more »

Hiv Anxiety or Hiv

Posted by jsw1, 1 Reply

My story is I had (one time) unprotected vaginal sex with a married women 5 years ago, whom I've known all my life. Least to say I feel horrible about the whole incident. I also was diagnosed with anxiety disorder in 2000. The only symptoms I've... Read more »

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