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Hiv Inhibitors

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Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
Ask the Experts

what is HIV PROTEASE INHIBITORS.

In taking hydroxyzine pam 25 mg,it states if you are on HIV Protease inhibitors, not to use. What is HIV Protease inhibitors?...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
HIV protease inhibitors are a family of HIV drugs (such as Kaletra, Viracept, Lexiva, Reyataz) used chronically for the treatment of HIV/AIDS.... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

HIV meds other inhibitors/ smoking

I am currently taking Combivir and Viracept and also am a heavy smoker. I want to quit but I think I might need some help from meds. With the HIV meds that I am currently on is it safe to take other inhibitors such as Zyban or is it safer to use...
Rick Stryker, M.D., M.P.H.

Response from Rick Stryker, M.D., M.P.H.

University of California Los Angeles School of Medicine
Quitting tobacco is a great idea, one of the best things you can do to increase your overall well-being. It is not clear, as we once thought, that smoking necessarily increases your risk of HIV progression. But it is still very important to stop,... Read more »

HIV & ACE inhibitors

Hi Doc, Infected 1989 at age 29. Started cocktail w/Combivir & Crixivan 1996 = Rt. kidney (due to Crixivan) stones 2001 & Lt. percutaneous nephrolithotomy for 3.5cm staghorn calculus (not related to HIV or meds) 2002. Switched to Combivir...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
ACE inhibitors are widely used in HIV + patients to control blood pressure and to help protect kidney function. I have scores of patients on various ACE inhibitors which are generally well tolerated though sometimes need to change from one (ie... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

Integrase Inhibitor

Posted by Survivor
I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply
Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »