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Hiv Entry Into Cd4 Antiviral Therapies

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AIDS InfoNet

Raltegravir (Isentress)

What Is Raltegravir? Who Should Take It? What About Drug Resistance? How Is Raltegravir Taken? What Are the Side Effects? How Does it React With Other Drugs? The Bottom Line What Is Raltegravir? Raltegravir (Isentress) is a drug used for antiviral therapy against HIV. It was formerly known as MK-0518. It is manufactured by Merck. Raltegravir is the first "integrase inhibitor" drug. When HIV infects a cell, it combines its...
Ask the Experts

Why CD4 goes down while CD4% goes up (ABSOLUTE CD4 COUNT VERSUS CD4%, 2009)

Hi Dr. Bob, it is a real pleasure to read your answers full of help, professionalism, generosity and fun. I started therapy at an absolute CD4 of 405 and 26% and VL above 100k, I started Atripla six months ago after the first three months my CD4...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hi,When it comes to monitoring HIV disease, it's important to look for long-term trends rather than worry about transient swings, especially in absolute CD4 counts. Absolute CD4 counts are calculated from the absolute lymphocyte counts. The... Read more »

CD4 Count V. CD4% Count (ABSOLUTE CD4 COUNT VERSUS CD4%, 2010) (WHEN TO START TREATMENT, 2010)

Hi,I was diagnosed with HIV around 15 months ago. Since then my health has been good (especially in the last six months) but my CD4 count has fallen a bit rapidly from 470 to 371 to 324 over this time period. However, my CD4 percentage count has...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,You are correct: The CD4% is generally considered the more accurate indicator of immune integrity, as it doesn't tend to fluctuate as much due to intercurrent illnesses and other non-HIV-related factors. (See below.)Regarding beginning... Read more »

Difference between CD4 and Percentage (CD4 count versus CD4%, 2011) (LACK OF CD4 RESPONSE DESPITE TREATMENT, 2011)

Could someone explain what exactly is the correlation between CD4 cells and percentage. I know what CD4 are but what does percentage mean. Also, I have been undetectable for 1 year now, my percentage has gone from 3 to 8 but cd4 rose to 320 from 130...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hi.This gets a bit confusing, but let me try to sort this out for you. A CD4 count is not a direct cell count of CD4 cells in your blood. Rather, it's a calculation based on the total white blood cell count and the proportion of those white... Read more »

Cd4 and CD4/CD8 ratio

Dear Keith, I have been recently diagnosed HIV+ (June 02) and have some questions regarding both the CD4/CD8 ratio and CD4 which do not seem to be spoken about as much as the CD4 absolute.My first question is what exactly are CD8 cells? What happens...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The rate of fall in CD4 count is quite variable. The normal situation is that there are more helper cells than suppressor cells so the helper/suppressor ration (CD4/CD8) is greater than 1.0. With HIV infection there is a fall in the helper cell... Read more »
Connect With Others

High VL/High CD4: what to do?

Posted by Anonymous, 7 Replies
Hi from Italy.
I'm HIV+ since Feb 00 and I discovered my status in June.
Since then I have regularly checked my situation having always high VL (from 60K to 240K) and high CD4 (from 750 to 1000).
My last analysis are VL: 200K and CD4: 907.
My doctor is... Read more »

IL-2 Induces Sustained CD4 Cell Increases

Posted by Anonymous, 1 Reply
IL-2 Induces Sustained CD4 Cell Increases in HIV-Infected Patients


By Deborah Mitchell

TORONTO, Sep 20 (Reuters Health) - The addition of recombinant interleukin-2 (IL-2) to an HIV antiretroviral therapy produces an increase in CD4+ T-cell counts,... Read more »

improving cd4 counts

Posted by terrrrrry2003, 2 Replies
Hi There everybody travelling on the positive train. I've been + for ten years now and been on meds for 4 years and then off them again for over three now ( with doctors approval ). As we all know, the bottom line is when the doc says " I think its... Read more »

Negative but with a very low CD4 and CD4/CD8

Posted by tobeabetterman, 1 Reply
Hi everyone , sorry to bother again .
I was once told by dear kicker and riverprincess that my 3 months result is conclusive , thank you very much with my best wishes , and I'm sorry I have bother you again .
Some new situation make me nervous again .... Read more »