Hiv Drug Resistance Update

Here's a taste of what TheBody.com has to offer on this topic:

Articles

Studies Examine "Sugar Daddy" Relationships in Africa, Drug Resistance in HIV Subtypes; kaiserEDU.org Updated With HIV/AIDS Information

"Confronting the 'Sugar Daddy' Stereotype: Age and Economic Asymmetries and Risky Sexual Behavior in Urban Kenya ," International Family Planning Perspectives : This report by Nancy Luke, an assistant professor at Brown University and a fellow at... Read more »

FDA Updates Black Box Warning on Boehringer Ingelheim's Protease Inhibitor Aptivus to Treat Drug-Resistant HIV

FDA and Boehringer Ingelheim on Friday updated the black box warning on Boehringer's protease inhibitor Aptivus, which is used in combination with Abbott Laboratories ' Norvir for people living with HIV/AIDS who have become resistant to other... Read more »

Atripla Label Update Reflects New Efficacy, Safety and Resistance Data in Treatment Experienced Patients

On January 7, 2010, FDA approved an updated Atripla label including new efficacy, safety and resistance data in treatment experienced patients from a trial ( Study 073: A Phase IV, Open-Label, Randomized, Multicenter Study Evaluating Efficacy and... Read more »

Ask the Experts

Multidrug resistance - update from 2007

Hello.A phenotype resistance test showed multidrug resistance in May of 2006. This includes all the active ingredients of Atripla.A few months later, I had genotype and phenotype tests repeated and they showed minimal resistance. In June 2007,...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

There are many important considerations in the story that you tell, but I would not conclude that repeat resistance tests are always needed when adverse results are received. Better to conclude that there are MANY good reasons to quickly repeat... Read more »

Are the undetectable viral copies more prone to being drug resistant and spawning many drug resistant viral copies?

Commercial assays only detec >50 copies of plasma VL. Is it possible/likely (?) that the <50 copies of virus may be the ones that are drug resistant?What are the reservoirs where dormant HIV resides and does the virus continue to do damage...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

Commercial assays only detect the majority species, so we are unaware of the mutations present on minority species, i.e. those with < 10-20% of the population. More sophisticated techniques have been developed which can detect resistance down to... Read more »

Are the undetectable viral copies more prone to being drug resistant and spawning many drug resistant viral copies?

Commercial assays only detec >50 copies of plasma VL. Is it possible/likely (?) that the <50 copies of virus may be the ones that are drug resistant? What are the reservoirs where dormant HIV resides and does the virus continue to do damage...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Given those numbers, you are not only immunologically intact, but cognitively as well. There may be areas of low level replication going on despite a plasma viral load < 50. Plasma viral load is only a measure of circulating virus being produced.... Read more »

Changing Drugs Before Resistance

Hi, I've been on HAART for two months now and have had great results and (knock on wood) no side effects from my Sustiva/Epivir/Videx combo. My doctor has told me that he switches people's combos before the virus becomes resistant, so...

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

The short answer is that it is an interesting but unproven approach. I am interested in seeing research to try it but I do not use that approach in my practice. It is hard enough to find a regimen that one tolerates and is effective.There has been... Read more »

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Connect With Others

Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

Drug Resistant HIV

Posted by Anonymous

Hi

I just found out the strain of hiv i have is resistant to possibly a whole class of NRTIs and PIs..any experience with this for any of you? what could the options be for someone in my situation? I am still treatment naive.

Read more »

New York draws fire over case of drug-resistantHIV

Posted by Anonymous

Nature 433, 788 (24 February 2005)

New York draws fire over case of drug-resistant HIV

ERIKA CHECK

Rare, aggressive form of AIDS used to publicize dangers of unprotected
sex.

[WASHINGTON] A decision by New York health officials to announce the
detection... Read more »

HIV and the brain - update

Posted by ScotCharles, 6 Replies

My neurologist at UCLA, Dr. Elyse Singer, has been warning since the mid 1990's that HIV's effect on the brain and nervous systems was a ticking timebomb. The meds never completely eradicate the virus from the body and never effectively cross the... Read more »

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