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Hiv And Protease Enzyme

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Get the Facts
The Well Project

HIV Drugs and the HIV Lifecycle

...integrated into) the CD4 cell, itcommands the CD4 cell to start making new HIV proteins. The proteins are thebuilding blocks for new HIV viruses. They are produced in long chains. Assembly An HIV enzyme called protease cuts the long chains of HIV proteins intosmaller pieces. As the smaller protein pieces come together with copies ofHIV's RNA, a new virus is put together (assembled). Budding The...
Ask the Experts

haart therapy and hiv genes

Of the nine HIV genes, which one according to HAART therapy would be the most dangerous if it were to mutate?
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Almost all HIV drugs work on HIV enzymes (reverse transcriptase and protease) that are co-located in the HIV-1 pol gene. Mutations in the gene sequences coding for these Read more »

Protease inhibitors

I like most HIV positive people are taking the protease inhibitor drugs. Is protease an enzyme? I ask this because I also drink wheatgrass juice on a daily basis and one of the enzymes it claims to boost is protease. What is the connection here?
Cade Fields-Gardner M.S., R.D.

Response from Cade Fields-Gardner M.S., R.D.

The Cutting Edge
...The job of protease inhibitors is to "inhibit" specific HIV protease enzymes. So, yes, proteases are enzymes, but protease inhibitors are not. Read more »

How do protease inhibitors work?

I was wondering how a protease inhibitor acts on the protease of HIV. What does this protease enzyme do that it needs to bestopped?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...Protease is an enzyme that cleaves precursor proteins into their final products during or shortly after the budding of the newly formed virus particle Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops Read more »
Articles
San Francisco General Hospital

How the Protease Inhibitors Work

...1, central blue band), which are essential to the maturation of the virus. Although the genetic sequence of the HIV protease enzyme was described soon after the discovery of the virus itself, the three-dimensional structure of the gene was not... Read more »
Gay Men's Health Crisis

Debate Widens Over Protease Inhibitor Side Effects

...and to use the term peripheral lipodystrophy. His group has consistently found very high prevalence rates among its cohort of protease inhibitor-treated patients. At the 5th Retrovirus Conference last winter, Dr. Cooper reported that 64% of his... Read more »
AIDS InfoNet

Protease Inhibitors in Development

...approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts... Read more »
U.S. Centers for Disease Control and Prevention

FDA Approves an AIDS Drug From Vertex

...Administration granted on Friday marketing authorization to Vertex Pharmaceuticals for Agenerase, the fifth drug targeting HIV's protease enzyme that has been approved for the treatment of AIDS. Vertex developed the drug, which will be marketed... Read more »
Connect With Others

Integrase Inhibitor

Posted by Survivor
...antiretroviral drugs, the San Francisco Chronicle reports (Russell, San Francisco Chronicle, 2/9). Integrase is one of the three enzymes necessary for HIV to replicate in the body, and integrase inhibitors would stop HIV from inserting its genes... Read more »

New meds in development

Posted by Anonymous, 3 Replies
...1990s, medicines have helped to reduce mother-to-child transmission of HIV by two-thirds. And since the mid-1990s, when the first protease inhibitors were launched and combination drug therapy was introduced, the U.S. death rate from AIDS has... Read more »

new meds in development as of Dec. 2002

Posted by Anonymous, 1 Reply
...the process. Another medicine in the pipeline the first in a new class called integrase inhibitors is designed to block an enzyme that the virus needs to make copies of itself. The first AIDS medicine was developed in 1987, four years after... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
...I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law Read more »