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Hiv-1 Protease

Here's a taste of what has to offer on this topic:
Ask the Experts

fda just approved 908, tell me why this is good?

Dr. Young, Hi I read that the FDA approved 908. Is this good and will this drug have activity against hiv-2 as well.Thanks,Sandy
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...the FDA just approved fosamprenavir (Lexiva, 908) for the treatment of persons with HIV-1 infection. The medication is a new HIV-1 protease inhibitor that offers improved potency (unboosted) and dosing flexibility. It appears to be very well... Read more »

Is this agent effective against hiv-2? low nanomolar concentrations (IC50 < 10 nM for HIV-1 protease). The inhibition constant (Ki)... Read more »

Solution to HIV?

...after the administration of a potent inhibitor of HIV-1 protease, it was estimated that... Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) Clinical Trials of HIV-1 Protease Inhibitors (Session 41) Immune Reconstitution (Session 45) Treatment of Primary Infection (Session 47)

...Katlama, N. Clumeck, S. Fenske, J. Mallolas, A. Lafeuillade, and L. Beauvais View the original abstract Clinical Trials of HIV-1 Protease Inhibitors (Session 41) Amprenavir (APV) 600mg/Ritonavir (RTV) 100mg BID or APV 1200mg/RTV 200mg QD... Read more »
The Body PRO

Clinical Trials of HIV-1 Protease Inhibitors

GW433908, a Novel Prodrug of the HIV Protease Inhibitor (PI) Amprenavir (APV): Safety, Efficacy, and Pharmacokinetics (PK) (APV20001) (Poster 333) Authored by R. Wood, K. Arasteh, R. Pollard, P. Kaur, O. Nadarer, and M. B. Wire View the original... Read more »
The Body PRO

Clinical Trials of HIV-1 Protease Inhibitors

Indinavir/Ritonavir Versus Indinavir in Combination with AZT/3TC for Treatment of HIV in Nucleoside-Experienced Patients: a Randomized, Open-Label Trial (Poster 335) Authored by M. Boyd, C. Duncombe, M. Newell, C. Ungsedhapand, K. Ruxrungtham, M.... Read more »
The Body PRO

Abstract No. 603: Resistance Profile and Drug Combination Studies of an HIV-1 Protease Inhibitor BMS-232632

This presentation by Gong and colleagues at Bristol-Myers Squibb provides in vitro data of a new protease inhibitor in development that promises desirable features of once daily dosing, good tolerability and a resistance profile that appears (at... Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting. I have just spoken to my son again. He was finally able to convince... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law seem not to... Read more »


Posted by Anonymous
Advanced Search Log In Home > News & Publications > Journals > AFP > Vol. 60/No. 2 (August, 1999) How to Recognize and Treat Acute HIV Syndrome BARBARA LEE PERLMUTTER, M.D., PH.D., JORDAN B.... Read more »

HIV-1 and HIV-2 ?

Posted by codymartinnc, 1 Reply
Test taken after 3 months of exposure. Got the antibody result, and was told NEGATIVE. Greatly appreciate if someone can provide details on specifics of the result. Below is the result: Tests performed by Lab Corp HIV 1/O/2 Abs, Qual Non Reactive ... Read more »