High Neutrophils Mitochondrial Toxicity

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Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...

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mitochondrial toxicity- what is it

Hi, Im taking 3tc, sustivia, and abacavir. Im experiencing lypo- who isnt it seems. What is mitochondrial toxicity and what caused it.Am I taking any medications which may contribute to it, and if so, some suggestions as to what else I might...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Lipodystrophy is not precisely defined but includes issues related to fat distribution (too much in some areas and loss of fat in others) and increases in blood fat levels. Some of those conditions are seen in the general population. Lipodystrophy... Read more »

thank you ! thank you!!! (Mitochondrial toxicity)

Thank you for your responses about mitochondrial toxcity and nukes.You have been so informative.I think alot of doctors don't take the time to explain in depth to their patients,because they think details may go over their heads,but I'm...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your warm comments.As you point out, the only accurate test for mitochondrial injury currently is a lactic acid level. The test is promblematic (difficult to do reliably) and probably only picks up late injury.There are several groups... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...

Response from Alvan Fisher, M.D.

Brown University School of Medicine

No, not routinely.Alvan Fisher, M.D.... Read more »

mitochondrial toxicity

I've been hearing a lot lately about mitochondrial toxicity and I know one of the most common signs of MT is muscle weakness. I'm 52 and have been positive for around 10 years. My viral load is 15,000 and my t-cell count 450. I'm not...

Response from Thomas N. Kakuda, Pharm.D.

University of Minnesota

Gary,Dysfunctional mitochondria in the muscles can lead to a condition known as "mitochondrial myopathy" which manifests itself as muscle weakness and fatigue. The famous cyclist Greg LeMond retired in 1994 due to this disease.... Read more »

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