Genetic Resistance To Hiv

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Articles

CCR5 Genetic Variation Responsible for Resistance to HIV Might Decrease Resistance to West Nile Virus, Study Says

People living with a genetic variation in the CCR5 receptors of their immune cells -- which has shown resistance to HIV -- might have an increased risk of contracting West Nile virus, according to a study published in the Jan. 17 online edition of... Read more »

Genetically Engineered, HIV-Resistant Cells: The Latest Breakthrough in HIV Gene Therapy

A new gene therapy could make a person's CD4+ cells resistant to HIV -- a method that, if successful, would eliminate the need for antiretroviral drugs for those living with HIV, according to a new study conducted by researchers at the Stanford... Read more »

Genetic Variation Responsible for HIV Resistance Not Caused by Black Plague, Study Says

Some people with a genetic variation in the CCR5 receptors of their immune cells are resistant to HIV, but a theory that the mutation was caused 800 years ago by selective pressure from the Black Plague appears to be unfounded, according to a study... Read more »

Ask the Experts

I am off HIV meds more than I am on, do I have good genetics or ?

Not exactly a question, but I have not been on steady HIV drugs in about 15 years. I was diagnosed in 1992. I am on Atripla now, but only take it for a few weeks at a time. When my Tcells drop to around 250 and my viral load is in the 10's of...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

It is great that you continue to be doing well clinically-there is a wide range of progression rates to serious clinical problems so you may be on the fortunate side of the scale. I do not recommend starting and stopping Atripla since it is highly... Read more »

Genetic sequence

Doc, If a person in not on any medications/treatment, does this mean if they infect you because of the wild type, you (being infected) will most likely not have any drug mutations contained in it's genetic sequence? ...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

Transmission of antiretroviral resistant strains of HIV has become an increasing concern following the detection of such drug resistant virus in a minority of recently HIV infected individuals.Certainly, the risk of acquiring a drug resistant... Read more »

Which HIV-1 Drug Resistance Mutations Are Common in Clinical Practice?

I know most mutations are polymorphisms...but which are most common and have significance for treatment?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Go to: http://www.iasusa.org, and on the left side tabs, go to resistance mutations. That will lead to a table that shows all the HIV medication associated mutations.... Read more »

Genotypic vs. Phenotypic resistance

What is the difference between genotypic and phenotypic resistance testing?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Genotyping utilizes molecular biology techniques to look at changes (mutations) in the genetic sequence of HIV that are known to confer resistance to various drugs. Phenotyping uses techniques to grow a patient's virus in a test tube in the... Read more »

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HIV tests that detect the genetic material of HIV

Posted by nomoreworry4me

HIV tests that detect the genetic material of HIV itself (rather than antibodies or antigens) are known as PCR tests. PCR stands for Polymerase Chain Reaction and is a common way of testing for a variety of different organisms. The overall process... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

Drug Resistant HIV

Posted by Anonymous

Hi

I just found out the strain of hiv i have is resistant to possibly a whole class of NRTIs and PIs..any experience with this for any of you? what could the options be for someone in my situation? I am still treatment naive.

Read more »

HIV resistent people

Posted by Anonymous, 5 Replies

This is a follow up on someone else post. What if there are HIV resistaent people out there. Maybe those symptoms we had was a serosonverion but maybe our body had a little extra oomph and killed it off. You cant tell me the millions of people out... Read more »

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