Fuzeon Mutation Resistance

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Enfuvirtide (Fuzeon)

What Is Enfuvirtide? Enfuvirtide, also called Fuzeon® or T-20, is a drug used for antiviral therapy. It is manufactured by Roche and Trimeris. Enfuvirtide is the first "fusion inhibitor" drug. When HIV infects a cell, it attaches to the outside of the cell. Then it "fuses" or joins itself with the cell. Enfuvirtide stops this process of fusion. This means that HIV cannot infect that cell. Who Should Take It? Enfuvirtide was approved in...

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starting with fuzeon if pi resistant?

Dear doc,I am very PI resistant since infection: mutations L90M and V82A, among other five secondary mutations.My doctor at the time (I had just seroconverted) recommended starting sustiva/combivir but I had to stop after a week because of grade 4...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Fuzeon is a potent agent, but has a number of disadvantages. These include twice daily injections, injection site reactions, and high cost. Based on your treatment history there is not a high chance that you have resistance to NNRTIs. I would be... Read more »

Fuzeon--Beneficial Despite Resistance?

Dr. Sherer,Is Fuzeon beneficial even when a patient is clearly resistant to it? My viral load dropped to 1800 after first month of treatment, then rose to more than 100,000 three months later. The high viral load has been reconfirmed....

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

In a small study that attempted to answer this question, the answer appeared to be yes, there is still value in taking Fuzeon, even in the presence of documented resistance. In this small study, there was substantial additional viremia when Fuzeon... Read more »

Resistance Shown to all drugs - time to add Fuzeon?

Tested HIV+ in 1985 (asypmtomatic). Started AZT 1984 and went through many HIV drugs. In 2000 stopped Crixivan & others (CD-4 229 & VL 13000) and started Kaletra & ziagen. Now my CD-4 is 291 and viral load is 16,000 (usually stayed...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

The devil is in the details. Fuzeon will only work effectively for you if there are at least 1, but more likely 2 other HIV drugs that also have activity. It will not work in a regimen, which shows complete resistance. That means fuzeon is acting... Read more »

FUZEON _Con fuzeon!

Hi and Thank you for being there for all of us! Thank you for accepting a bit of colorful expression enclosed.I'm HIV+ for 161/2 years and I have CD4 of 397 and vl of 14,000 to 44,000 and I've had to change doctors lately (long history -...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thank you for your post and comments. It's always good to hear that our forums are informative and worth recommendation to others. Confusion (or confuzeon) is not unusual for people in your situation. I like the pun (though I'm sure... Read more »

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Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

mutation

Posted by drnsee, 3 Replies

I'm aware that the HIV virus itself may mutate over time. However, my partner who has had HIV twice as long as I have heard that it actually mutates your own [human] DNA. That it integrates into your system so much that this happens over time.

I'm... Read more »

FUZEON

Posted by Monchhichi, 2 Replies

Just a question I want to get feedback on...To anyone on Fuzeon...What type of side effects are you getting and injection site reactions? Does anyone have any tips they can give on ISR's? My husband has been on Fuzeon for over a year now and any... Read more »

new to Fuzeon

Posted by Tscotty, 4 Replies

Last month after 13 years, millions of pills, and all the other stuff we go through - I saw "the" lab results indicating my complete resistance to every drug I have taken. Thursday I gave my first fuzeon injection -it sure was a scene. I actually... Read more »

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