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Fuzeon Mutation Resistance

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Get the Facts
AIDS InfoNet

Enfuvirtide (Fuzeon)

...your viral load and increase your CD4-cell counts. This should mean staying healthier longer. What About Drug Resistance? The HIV virus is sloppy when it makes copies of its genetic code (RNA). Many new copies of HIV are mutations: they are slightly different from the original virus. Some mutations can continue to multiply even when you are taking an antiviral drug. When this happens, the drug will stop working. This is called...
Ask the Experts

stanford HIVdb genotype algorithm

I have been on fuzeon for over 5 years. Very low body weight hardly no subq fat. Have injected every part of body possible. Never been undetectable. VL 301 t-cell 325. TC % 33 a 5% drop over past year. Resistance test indicates resistance to all...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Good for you for plug those numbers in! I think your choice is a good one and would predict that you will get your viral load undetectable with that regimen. Read more »

Fuzeon--Beneficial Despite Resistance?

Dr. Sherer,Is Fuzeon beneficial even when a patient is clearly resistant to it? My viral load dropped to 1800 after first month of treatment, then rose to more than 100,000 three months later. The high viral load has been reconfirmed.
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
...benefits in terms of the reduced fitness of the virus. Each resistance mutation 'costs' the virus something. Some resistance mutations, e.g. for the NRTIs, appear to cause significant reductions in viral replication capacity, i.e the ability of... Read more »

Stopping t-20

I have been on T-20 for a little over 19 months. I am getting weary of taking the shots twice daily. I have undetectable viral load and my t-cells have been hovering around 350. My other medications are Prezista, boosted with Norvir and Turvada. ...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
...Fuzeon is doing the heavy lifting in the regimen, losing it may raise the risk of viral rebound. Those with many NRTI and PI mutations may be in such a situation. These new drugs may or may not be able to so the same. In the absence of hard... Read more »

Resistance Shown to all drugs - time to add Fuzeon?

Tested HIV+ in 1985 (asypmtomatic). Started AZT 1984 and went through many HIV drugs. In 2000 stopped Crixivan & others (CD-4 229 & VL 13000) and started Kaletra & ziagen. Now my CD-4 is 291 and viral load is 16,000 (usually stayed around 7000). Due...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...pretty respectable. Obviously you would want it higher. But you are not in dire straights at this point. Depending on what PI mutations are present, you might want to wait until tipranavir (new PI that works against many PI resistant strains)... Read more »
Articles
The Body

What Exactly Is a Mutation? And What Are All Those Numbers About?

... To make it easier to work with HIV resistance tests, researchers have a shorthand system for naming HIV mutations. An HIV "mutation" is actually just a slight change in a specific section of HIV's RNA, the genetic code that provides all the Read more »
The Body

What We Know About Fuzeon

...which only Fuzeon was used to fight HIV clearly established this. This resistance is made apparent in the form of "genotype mutations ," although there are few if any commercial tests that can do such testing now. What remains less clear so far... Read more »
The Well Project

HIV Drug Resistance

...new viruses, HIV must copyits genetic information. Copying happens so fast that mistakes are made. Thesemistakes are called mutations, and they occur randomly. Some mutations are harmless. They produce weak viruses that can't infectother CD4... Read more »
The Well Project

HIV Drugs and the HIV Lifecycle

...different classes in order to attack HIV atmore than one step in its lifecycle. This is because HIV can make mistakes,called mutations, when it reproduces. Certain mutations prevent certain HIVdrugs from working. When this happens, we say that... Read more »
Connect With Others

Resisting Resistance - A Story

Posted by Survivor, 1 Reply
...not knowing that I was getting little, if any, benefit from ddC. I probably had already developed resistance to AZT, allowing mutations to occur and beginning my ride on the resistance roller coaster. Shortly after this, I developed my first... Read more »

mutation

Posted by drnsee, 3 Replies
I'm aware that the HIV virus itself may mutate over time. However, my partner who has had HIV twice as long as I have heard that it actually mutates your own [human] DNA. That it integrates into your system so much that this happens over time. ... Read more »

maintaining hope

Posted by breathe, 3 Replies
...and genotype testing have shown i have extreme resistance i think i may have one regiment that may work and it would include fuzeon....im just trying to remember we are not guaranteed any amount of time on this planet and to keep on plowing... Read more »

info

Posted by Anonymous, 1 Reply
...(NNRTIs), and protease inhibitors (PIs). However, the mans virus was susceptible to the fusion inhibitor T-20 (enfuvirtide, Fuzeon) and the NNRTI efavirenz (Sustiva). According to an update issued March 29 th by the New York City Department of... Read more »