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Facts About Protease Inhibitors

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
Ask the Experts

Why switch my protease inhibitor when it's working?

Dear Doc,My HIV specialist has suggested I consider changing the protease inhibitor in my regimen. I have been taking Kaletra (with Epzicom) since my diagnosis in late 2005. Most recent blood work shows undetectable virus and 802 T-cells. I take...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
The only reason to switch, particularly to reyataz, would be a more favorable lipid profile. In other words, reyataz doesn't raise lipids as much as kaletra so you might not have to take the tricor. Other than that, I see know reason to change... Read more »

2 lbs a month- Antipsychotics, antidepressants and protease inhibitors

Hi NelsonI have been gaining an average of 2lbs a month for the last few years and now find myself 100lbs over weightMy doctors are concerned and want me to lose weight.I have looked into the Lap Band and Lap Sleeve but none of my doctors think that...
Nelson Vergel, B.S.Ch.E., M.B.A.

Response from Nelson Vergel, B.S.Ch.E., M.B.A.

Program for Wellness Restoration
RayMany people on Risperdal gain weight more than anyone gains weight on boosted protease inhibitors, and combining those two medications may actually make things worse when it comes to weight gain. However, it seems that Risperdal causes less... Read more »

Hypogonadism from protease inhibitors

I am a 33-yr-old male who was diagnosed two years ago during my seroconversion illness, and immediately began triple cocktail therapy with Crix/AZT/3TC, and have remained undetectable since that first diagnostic viral load test. After 13 months of...
J. B. Molaghan, N.P., A.C.R.N.

Response from J. B. Molaghan, N.P., A.C.R.N.

San Francisco General Hospital
HelloThanks for such a nicely detailed clinical summary. Although we assume that hypogonadism is only associated with HIV disease progression, we don't really know if it occurred in early HIV disease, because we never looked for it. In fact,... Read more »

Protease Inhibitors vs. Triple Nucleosides

In late June my doctor gave me the option to change my HIV medication to Trizivir, from Viracept and Combivir. The dosage (two pills a day as opposed to twelve pills a day), was very tempting. I questioned him about the lack of a protease inhibitor...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
A few comments to see what I can do to clarify what you've read.First - the guidelines. They do comment on some of the protease inhibitors that they recommend as part of a first combination, such as Viracept. They also comment on other... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »