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Facts About Lipodystrophy

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AIDS InfoNet

Body Shape Changes (Lipodystrophy)

No researcher has suggested that people with lipo should stop taking ART. What Causes Lipo? We do not know what causes lipo. There are different causes for fat loss and fat gain. Fat Loss Zidovudine (Retrovir, AZT) and stavudine (Zerit, d4T) are linked to fat loss. Efavirenz (Sustiva) may also contribute. Fat Gain One theory is that protease inhibitors interfere with the body's processing of fat. However, some patients who have never...
Ask the Experts

hypercortisolism and lipodystrophy

I think many of us are frustrated by the slow pace of answers for the problem of lipodystrophy. Time and again we read that there are many questions and few answers. In particular, I'm frustrated by the apparent inattention paid to the theory...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The data is mixed on that but good groups have also reported little association between altered cortisol levels and the manifestations of lipidystrophy/HIV related metabolic disturbances. Another theory is that altered insulin function is a common... Read more »


does combivir and aluvia cause lipodystrophy...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thank you for your post from outside the US.First, let's be clear that there are factors other than medications that are also drivers of risk of developing lipodystrophy. Having a low CD4 count (ie, waiting too long to start medications) is... Read more »

RAPID lipodystrophy

Why does it seem like there is little new information about how to treat lipo? I am poz 14 years and except for a few blips---0 viral load. Literally in the last month my legs have become incredibly vascular and smaller, my waist has increased by 5...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
I agree that there is still much to learn regarding what is causing lipodystrophy and how to manage it. It is further complicated by the fact that it behaves differently in all people, some experiencing more of the fat loss, some the fat gain and... Read more »

Lipodystrophy, Thin Skin, and Easy Skin Damage

Dr. Henry,I've read some posts about people saying they get cut easy or suffer from dry skin and other issues.I have a friend who is HIV positive and has Lipodystrophy in the arms and legs. It's not extreme, but he does notice less fat...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Thanks for those worthwhile comments on a frustrating topic. KH... Read more »
Connect With Others


Posted by Anonymous, 2 Replies
Is anyone suffering from lipo, without really too much fat loss?I'm getting really big, but haven't experienced the thin legs thing yet(in fact my thighs are pretty mushy and fat)I'm wondering if the loss part usually happens first or second?Also,... Read more »

exercise and PI lipodystrophy

Posted by Anonymous, 3 Replies
i have been on zerit, epivir and crix for more than one year.
i have lipodystrophy (no more buttocks, fat loss in face and a paunch). I have always been an avid exerciser -- my doc has told me to STOP exercising, that it worsens the situation.
i... Read more »

I'm trying not to scare anyone, but facts are fact

Posted by Anonymous, 6 Replies
In fact I'm not trying to scare anyone, and I don't want to make a kid's game out of the Bulletin Board. I'm just trying to make everyone realize that 99,9% of people doesn't cover all individuals, when talking about tests... I'm sure that 999 of... Read more »


Posted by Anonymous, 1 Reply
anyone who will talk about this?

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