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Facts About DdI

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AIDS InfoNet

Didanosine (Videx, ddI)

... What Is Didanosine? Who Should Take Didanosine? What About Drug Resistance? How Is Didanosine Taken? What Are the Side Effects? How Does Didanosine React With Other Drugs? What Is Didanosine? ddI (Videx) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb and by Barr Laboratories. Didanosine is also known as ddI or dideoxyinosine. Generic versions have been tentatively approved
Ask the Experts


According to drug company literature and different source of imformation viread is supposedly less toxic and not as likely to cause mitochondrial toxcity as ddi.How can this be,if they are both anologues of adenine?I would think the side effects...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...Thanks for your question.Yest both didanosine (Videx) and tenofovir (Viread) are both adenosine analogues. Past this, the two drugs have very dissimilar structures, and dissimilar Read more »

DDI - Peripheral neuropathy

I have been HIV positive since 1985. I have severe neuropathy. I havedeveloped resistance to the antivirals I've been taking.My doctor has ordered Didanosine (DDI). What are the chances of the DDImaking my neuropathy worse? THANKS FORYOUR HELP!
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...Yes, if you have severe neuropathy, ddI could definitely make yourneuropathy worse. The "d-drugs" (ddI, ddC, or d4T) are contraindicatedin someone who has severe neuropathy. Read more »

DDI questions

Why would my doctor perscribe the chewable twice daily tablet rather than the capsule? Is there any reason other than maybe he did not know about the capsule?I have taken DDI in mid 90s and I quit taking it because it made me sick. I got a huge hump...
Brian Boyle, M.D., J.D.

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College
...only 9% at 48 weeks, which is very low for any antiretroviral regimen. I agree that there is little reason for using Videx (didanosine) tablets now that Videx EC is available. It is much better tolerated, and many of my patients who didn't... Read more »

DDI or D4T

Hi, I was on d4t for five months and it started giving me tingling/hypersensitive to touch feet. My doc wanted to change to DDI. Is it a good idea, i understand DDI has the same effect as D4t?
Judith A. Aberg, M.D.

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine
...Both D4T and DDI can cause peripheral neuropathy. I have had some patients that appear more sensitive to one nucleoside over the other but if Read more »

An Overview of Videx (Didanosine, ddI)

... Brand Name: Videx EC, Videx Other Name(s): BMY 40900, BRN 3619529, CCRIS 805, Didanosina, Dideoxyinosine, HSDB 6548, ddI Drug Class: Nucleoside Reverse Transcriptase Inhibitors Didanosine, also known as ddI or Videx, is a type of... Read more »
The Body PRO

Abstract No. 402:Phase I/II Dosing Study of Once-Daily Hydroxyurea (HU) Alone vs Didanosine (ddI) Alone vs ddI + HU

...In earlier studies, hydroxyurea, when added to DDI or D4T increased the activity of a single or dual nucleoside therapy by 0.5 to 0.7 log 10 copies/mL. The authors, in this placebo Read more »
The Body PRO

Abstract No. 402: Phase I/II Dosing Study of Once-Daily Hydroxyurea (HU) Alone vs Didanosine (ddI) Alone vs ddI + HU

...a phase I/II, randomized, placebo-controlled five-arm study comparing HU alone at two doses (1000 mg a day and 1500 a day), ddI alone (200 mg twice a day), and ddI/HU in treatment naïve and experienced subjects. The HU groups had ddI added after... Read more »
The Body PRO

Safety and Efficacy of Once-Daily Dose of Didanosine (DDI)

...Dr. E. Martinez and colleagues from Barcelona, Spain, reported on 80patients who received ddI once a day, plus D4T 40 mg bid, with or withoutsaquinavir or indinavir. The mean baseline CD4 count was 178 cells/mm3, andthe Read more »
Connect With Others

taking ddi

Posted by Anonymous, 1 Reply
...Taking ddi (Videx)? Do you drink alcohol? My Dr. says I should have no alcohol as it increases the risk of getting pancreatitis. Read more »

Sustiva or DDI/hydroxurea

Posted by Anonymous, 2 Replies
...I am a female recovering addict and have been clean for over ten years. I am getting real weird side effects from Sustiva and even though I started taking Read more »

My partner was put on DDI

Posted by Anonymous, 1 Reply
...Hi, My partner is HIV+ and has recently been put onto DDI and AZT. I think, as a consequence, has become one of the most unfriendly, annoying people in the world. Is this common, have Read more »

50% of HIV+ Develop Neurocognitive Impairment

Posted by ScotCharles, 3 Replies
...remembering, planning, making decisions, attentional abilities, concentration; those kinds of skills are under "neurocognitive." In addition, a subset of these patients received brain-imaging studies, including studies of the structure of their... Read more »