Facts About Aptivus

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Get the Facts

Tipranavir (Aptivus)

What Is Tipranavir? Tipranavir is a drug used as part of antiretroviral therapy (ART). It is also called Aptivus. It is manufactured by Boehringer Ingelheim. Tipranavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissors. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these scissors. Who Should Take It? ...

Ask the Experts

Aptivus

Doc,I've read a lot about Aptivus being good for people who have had resistance to other drugs. Is it ever used for people just starting treatment? As someone who has recently tested positive I'm weighing all my options.Thanks! Rob...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Aptivus is also known as tipranavir and is a recently approved protease inhibitor that has activity against virus that is multi-drug resistant. It is typically used as part of a salvage regimen for patients that have drug-resistant virus. There are... Read more »

What to do - Aptivus?

Doctor, vircotype phenotpype showed mutations at 41L, 43Q, 118I, 210W, 211K and 215S and said I had susecptibility to all NRTI's, "maximal" to retrovir. No nNRTI mutations. PI mutations at 10I, 13V,, 33F, 46I, 48V, 54T, 71V, 74S,...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. The best answer to your question will depend on some additional information: viral load, CD4 count, previous treatment history, prior resistance tests, and any known antiretroviral medications intolerances. The short... Read more »

RE What to do - Aptivus

Doctor, thank you for your speedy response. To answer your question, I am six years poz. Treatment naive. Last VL's over the past year ranging 250 to now 158. About 8% each time CD4 to CD8. I know I have these NNRTI mutations...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

It is quite unusual, but not unheard of, to have so many resistance mutations in someone who is nave to treatment. But based on the resistance test from your previous <a... Read more »

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain)... Read more »

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I'm trying not to scare anyone, but facts are fact

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ITS A FACT

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Facts II. WIndow Period

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