Facts About NNRTIs

Here's a taste of what TheBody.com has to offer on this topic:

Articles

Know Your HIV Drugs: NNRTIs

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs are another class of FDA-approved HIV antiviral drugs. There are currently three drugs approved for use in this class. NNRTIs work by targeting the structure of reverse transcriptase... Read more »

Drug Watch: Next-Generation NNRTIs: Etravirine and Rilpivirine

Why Do We Need More NNRTIs? Leading the Next Generation: Etravirine and Rilpivirine Etravirine: The DUET Studies Rilpivirine Implications for Treatment Selected Sources Even in patients with the most resistant virus, our goal now is full... Read more »

NNRTIs: The Next Generation Approaches

Part I Introduction Mechanisms of NNRTI Activity and HIV NNRTI Resistance NNRTI Resistance in NNRTI-Naive and NNRTI-Experienced Individuals NNRTI Mutations: Resistance and Cross-Resistance NRTI Mutations: The Potential Impact on NNRTIs NNRTI... Read more »

Ask the Experts

NNRTIs

Are either of the newer NNRTIs, Edurant or Intelence processed differently by the liver than the older drug Viramune? I have been on Viramune for more than 10 years just wondering of switching to one of the newer ones would be considered more...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The major liver concern with nevirapine is early on treatment. After 10 years the rate of liver problems on nevirapine would be expected to be low. Though etravirine and rilpivirine may be viewed as being more liver friendly there is minimal very... Read more »

Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation at codon 106 in HIV-1 clade C viruses that occurs after exposure to efavirenz appears to result in high-level resistance to other non-nucleotide...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for pointing out the research.So far, this does not seem like a very common issue-- however, a different mutation at codon 103 is commonly found among persons with clade B HIV (the US, Western Europe flavor)- this mutation usually causes high... Read more »

NNRTIs and lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've been on Sustiva/Truvada for 14 weeks with great results but have been battling high cholesterol for about 10 years, HDL high, LDL low, well controlled...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Lipitor and other statins are not on the absolutely contraindicated list on the FDA approved package insert for sustiva. With anything you just need to be careful and have close followup.... Read more »

True fact?- 6 months until detection of hiv /aids

Is it a true fact that it takes up to 6 months from unprotected sexual encounter to detect in testing if you have came across and been infected with hiv/aids? How long does it really take from sexual encounter for hiv/aids to enter your body system...

Response from Richard Cordova III

Test Positive Aware Network

Hi there:No. That is incorrect. The answer is three months. It takes three months for the body to produce enough antibodies to be detected by an antibody test. At 90 days you can get a conclusive HIV test result. In health,Richard... Read more »

Go to Ask the Experts »

Connect With Others

I'm trying not to scare anyone, but facts are fact

Posted by Anonymous, 6 Replies

In fact I'm not trying to scare anyone, and I don't want to make a kid's game out of the Bulletin Board. I'm just trying to make everyone realize that 99,9% of people doesn't cover all individuals, when talking about tests... I'm sure that 999 of... Read more »

ITS A FACT

Posted by Anonymous

Its a fact some of positive people lie about their status before sex. If you are going to have sex BE SAFE! dont believe people if they tell you they are negative, they may not be. ALWAYS PRACTICE SAFE SEX!!!!! I hope we learned something here.

Read more »

HIV FROM CONDOMS AFER FACT?

Posted by Anonymous, 2 Replies

What are the chances of catching hiv when:
You have sex with a male with the condom on, after he cums he pulls the condom off and you play around for around 10 minutes he puts his penis in you for a couple of seconds (about 2 inches)? Read more »

Facts II. WIndow Period

Posted by Anonymous, 3 Replies

Without having to travel so far away, you can find posts of Dr. Santana (The Body Spanish section) where he refers to the window period in a very similar way to what I said before,
In one of his posts he says: test at 3 months, at 6 months, at 9... Read more »

Connect on Our Bulletin Boards »

Tools

My Health Tracker

Assess Your Risk for HIV

Find Local HIV/AIDS Services

Resource Centers

Guides for People With HIV

View All of Our Guides >>