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Efavirenz And Liver Disease

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AIDS InfoNet

Efavirenz (Sustiva)

What Is Efavirenz? Efavirenz is a drug used as part of antiretroviral therapy (ART). It is also called Sustiva or Stocrin. It is manufactured by Bristol-Myers Squibb. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Efavirenz is a non-nucleoside reverse transcriptase inhibitor (a "non-nuke" or NNRTI). These drugs stop HIV from multiplying by preventing the reverse transcriptase enzyme from working. This enzyme...
Ask the Experts

Liver Disease and HIV

HiI wrote you before but you never answered my question. My cousin's 3 year old son was just diagnosed with liver disease and she said he was born with it - but she tells us that he has HIV. What exactly does this mean? Does this mean that...
Judith A. Aberg, M.D.

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine
You should ask your cousin for clarification. You do not have enough information or you may have misunderstood what your cousin said. I suggest you talk to your cousin and ask her what he has. Not everyone who has liver disease has HIV and not... Read more »

Decompensated LIver Disease

With cirrohsis & early decompensated liver disease(HCV 2a elevatedast/alt at 190/200)can I take interferon/ribivarin w/close monitoring...
Barbara McGovern, M.D.

Response from Barbara McGovern, M.D.

Tufts University School of Medicine
I would discuss this question wiht an experienced hepatologist thoroughly since it is easy to treat genotype 2 infection. However, any signs of decompensation concern me regarding the use of interferon so please seek a very experienced specialist.... Read more »

End stage liver disease

My husband has end stage liver disease,Hep C,diabeties and annemia. He is haveing a hard time swollowing at times and has a sharp pain that comes and goes in his back he says he feels like fluid is flowing down his spine. Once a week he has nose...
Barbara McGovern, M.D.

Response from Barbara McGovern, M.D.

Tufts University School of Medicine
If your husband has not been drinking for 3 years, yes I would take him to a center that has a liver tranplant program for evaluation.Dr. M... Read more »

Alcoholic Liver Disease and HIV

I have recently been diagnosed with two things: alcoholic liver damage (moderate), and HIV. How will my body tolerate the medications? And for how long? Are there any medications for HIV that do not need to go through the liver? Please answer...
Barbara McGovern, M.D.

Response from Barbara McGovern, M.D.

Tufts University School of Medicine
Treatment for HIV is very important to slow down liver disease progression. Several studies suggest that suppression of HIV is a good thing for the liver. Many of the newer drugs developed over the last few years are very "liver... Read more »
Connect With Others

The treatment information of Liver diseases

Posted by wang

I am the administrator of the forum which provides discussion to patients with liver diseases (hepatitis c, fatty liver, liver cancer, liver cirrhosis, and NASH liver). You can get much useful information about liver health and let others share your... Read more »

Liver cancer, heart disease, counts, resistance

Posted by ScotCharles, 3 Replies
Generally, people develop resistance to Sustiva quickly since only one protein needs to mutate in the virus to render the drug ineffective. Monitor your counts closely and ask your doctor for a resistance panel if your counts change for the worse.... Read more »

Liver Tumours?

Posted by Anonymous, 1 Reply
I posted earlier on my bout with pancreatitis, thanks for all your kind replies. Unfortunately, a tumour or possibly tumours have been found, my lipase/amylase is higher than when I was admitted to hospital, and my liver function is abnormal. If... Read more »

LIVER ENZYME LEVELS

Posted by steelah343, 1 Reply
I just recently had an HIV test for the first time. I'm currently waiting results.
The impetus for the test was an increase in liver enzyme levels, which my doctor tells me have doubled (from 20s to 40s) in the past two years.

Again, I'm not certain... Read more »