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Do I Need To Take Protease Inhibitors

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
Ask the Experts

Therapy without a Protease Inhibitor

Viracept was causing erratic diarrhea. My doctor switched me to Kaletra. My combo is currently Kaletra, Videx, Viramune, and Viread. The side effects of the Kaletra are worse than those of the Viracept. Can a combo therapy work without a protease...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
You are on a triple class combination regimen, which suggests to me that this is not your first HAART combination. It may be that, in your setting, you need the protease inhibitor to produce maximal virologic suppression. The best way to determine... Read more »

How do protease inhibitors work?

I was wondering how a protease inhibitor acts on the protease of HIV. What does this protease enzyme do that it needs to bestopped?...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
Protease is an enzyme that cleaves precursor proteins into their final products during or shortly after the budding of the newly formed virus particle from an infected cell. If the proteins necessary for making new virus particles cannot be... Read more »

When to start Protease Inhibitors

I have Aids. My t-cell count is 86 and Im about to get the results from my first viral load test. My doctor has had me on what I feel as a strange concoction for some time(1 year D4t alone then after drop in t-cells AZT and D4t with a bactrim...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
Since your CD4 count is 86, a combination regimen that includes a protease inhibitor seems quite reasonable, regardless of what your viral load is. If your viral load is high, that would be further evidence for the need for a protease inhibitor.... Read more »

Xanax and protease inhibitors

I was diagnosed several years ago with panic disorder and have managed well to keep it under control with the use of xanax from time to time when stress gets really bad. But I understand that there is a concern about using xanax when using a...
John A. Bartlett, M.D.

Response from John A. Bartlett, M.D.

Duke University Medical Center
The issue with Xanax and protease inhibitors is the prolongation of the Xanax drug levels (and effects). Both drugs are metabolized by the same pathway in the liver, so that your Xanax will stay with you longer when you are taking a PI. The same... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »