Do I Need To Take Zidovudine

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Get the Facts

Zidovudine (Retrovir, AZT)

What Is Zidovudine? Who Should Take Zidovudine? What About Drug Resistance? How Is Zidovudine Taken? What Are the Side Effects? How Does Zidovudine React With Other Drugs? What Is Zidovudine? Zidovudine (Retrovir) is a drug used for antiretroviral therapy (ART). It was first manufactured by GlaxoSmithKline. It is manufactured by ViiV Healthcare. The patent on zidovudine expired in 2005 and several generic versions have been...

Ask the Experts

Switch from Zidovudine

My wife with a baseline CD4 of 83 (12.8%), and viral load of 2071 is on Zidovudine, Lamivudine, and Nevirapine for 6 weeks. She is also taking Bactrim DS for 2 weeks. While she has tolerated the drugs, she has recently reported a decline in white...

Response from Brian Conway, M.D.

University of British Columbia

You ask a very analytical question. Your doctor is right in that the combination of Bactrim and zidovudine may be particularly bad for the white blood cells, especially in someone who is deficient in folate. Sometimes, before making any changes in... Read more »

ZIDOVUDINE

I am working in treatment advocacy with HIV patients. Recently one of my patients stated that she was told by a kidney specialist that 300 mg of Zidovudine is to strong for her liver. she is having difficulty having the recommended dose of 100 mg...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

It is somewhat unusual for standard doses of zidovudine to be too strong for the liver . If she is seeing a kidney specialist and has some degree of kidney failure then the dose of lamivudine may be too high for her kidneys and the dose may need to... Read more »

Tenofovir, lamivudine+zidovudine and Kaletra as pep

Dear Doctor,I had a possible sexual exposure to HIV and managed to start pep about 30 hours after the high-risk situation. I live in Brazil, and it was really hard to get this treatment, but now I'm afraid my regimen was no correctly chosen....

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello and thanks for posting.You indeed are receiving an unusual PEP regimen.1) It's not likely to be ineffective, rather just more than needed.2) You're on day 23 of a planned 28 (or 30), I'd try to complete the treatment course if... Read more »

Underdosage of Zidovudine

Dear SirI am writing for the 2nd time. My son aged 5 years has been recently diagnosed as HIV+ His CD4 is 384. His doctor started him on Zidovudine 6ml twice a day, Lamivir 6.5 ml twice a day, and Nevirapine (initially 6 ml once a day). His weight...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.This reply comes from our good friend and colleague, Andy Pavia, MD from University of Utah:I don't think there is any risk at all from 2 weeks of underdosing of zidovudine. First of all, zidovudine resistance develops... Read more »

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