Do I Need To Take Zidovudine

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Get the Facts

Zidovudine (Retrovir, AZT)

What Is Zidovudine? Zidovudine (Retrovir) is a drug used for antiretroviral therapy (ART). It was first manufactured by GlaxoSmithKline. It is manufactured by ViiV Healthcare. The patent on zidovudine expired in 2005 and several generic versions have been approved. Several are available under PEPFAR (see Fact Sheet 475 ). Zidovudine is also known as azidodeoxythymidine, AZT or ZDV. Zidovudine was the first drug approved for the treatment of...

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Switch from Zidovudine

My wife with a baseline CD4 of 83 (12.8%), and viral load of 2071 is on Zidovudine, Lamivudine, and Nevirapine for 6 weeks. She is also taking Bactrim DS for 2 weeks. While she has tolerated the drugs, she has recently reported a decline in white...

Response from Brian Conway, M.D.

University of British Columbia

You ask a very analytical question. Your doctor is right in that the combination of Bactrim and zidovudine may be particularly bad for the white blood cells, especially in someone who is deficient in folate. Sometimes, before making any changes in... Read more »

ZIDOVUDINE

I am working in treatment advocacy with HIV patients. Recently one of my patients stated that she was told by a kidney specialist that 300 mg of Zidovudine is to strong for her liver. she is having difficulty having the recommended dose of 100 mg...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

It is somewhat unusual for standard doses of zidovudine to be too strong for the liver . If she is seeing a kidney specialist and has some degree of kidney failure then the dose of lamivudine may be too high for her kidneys and the dose may need to... Read more »

Underdosage of Zidovudine

Dear SirI am writing for the 2nd time. My son aged 5 years has been recently diagnosed as HIV+ His CD4 is 384. His doctor started him on Zidovudine 6ml twice a day, Lamivir 6.5 ml twice a day, and Nevirapine (initially 6 ml once a day). His weight...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.This reply comes from our good friend and colleague, Andy Pavia, MD from University of Utah:I don't think there is any risk at all from 2 weeks of underdosing of zidovudine. First of all, zidovudine resistance develops... Read more »

atripla and zidovudine

if somebody becomes resistant to atripla components would he necessarily become resistant to zidovudine as well? i hope not because in a paper i saw point mutations caused by 3 components of atripla are absolutely different from that caused by...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello and thanks for posting.There is a potential for cross resistance among the components of treatment. This means that prolonged treatment failure of one NRTI regimen has the potential to cause significant cross resistant to other medications of... Read more »

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