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D4T And Aids

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Get the Facts

An Overview of Zerit (Stavudine, d4T)

... STAV-yoo-deen Brand Name: Zerit Other Name(s): BMY-27857, Estavudina, d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Stavudine, also known as Zerit or d4T, is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). Stavudine works by disrupting one of the early steps in the HIV life cycle, called reverse transcription. During normal
Ask the Experts


With all the new meds out over the last 4 or 5 years:T20,apt/rit,Prezista,raltegravir,marivoc,entravine there seems to be no reason to use this toxic agent at all and if it is being used it should be eliminated as soon as any toxicity is observed....
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...d4T (Zerit) is rarely used in the US for the treatment of HIV-- reserved for unusual cases of drug resistance. d4T is still widely Read more »

treatment options to d4t/ fat wasting

first thank you for your help. It is appreciated. I have been on D4T(along with other drugs) for about 3 years. I have facial wasting and have read many answers to questions in another forum implicating D4T as one of the possible causes of facial...
Rick Stryker, M.D., M.P.H.

Response from Rick Stryker, M.D., M.P.H.

University of California Los Angeles School of Medicine
...adequately controlled. However, I am aware of one study (Saint-Marc, et al. AIDS. 1999; 13:pg2493-2505) where 11 patients switched D4T to Abacavir (probably your best choice given what you have said) and some patients had increases in... Read more »

facial wasting

dr young iam the same person from india .ireading inother forums of the body that person above 40 years starting with d4t and 3tc ie my medicines may have problems with facial wasting and lipodystrophy quicly .doctor what do you suggest .please...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...I did in my previous life, but I'm very happy to assist.Lipoatrophy can be a troubling issue for many patients. Stavudine (d4T) one of the components of your current drug regimen has been associated with an increased risk of developing... Read more »

stopped kaletra,ziagen,D4t -still experiencing side effects

I have been feeling very ill - my whole body is shaky,weak and(vibrating), I've had a headache for 4 days (even Imitrex) would not alleviate symtoms and extreme fatigue. I was worried that these were side effects from Kaletra,or Ziagen portion of my...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...You don't mention what your recent HIV levels or CD4 counts are or what your lowest CD4 count and highest HIV level or whether you have ever had an AIDS defining condition Read more »
International Association of Physicians in AIDS Care

A Note to Physicians: Important Information on the Combination of Zidovudine (ZDV) and Stavudine (d4T) in ZDV-experienced HIV-Infected Patients

...weeks. An interim analysis of this study revealed that the average CD4+ T cell count in patients taking the combination of d4T and ZDV decreased from the time they entered the study. NIAID recommends that physicians closely monitor the CD4+ T... Read more »
The Body PRO

Abstract No. 420: A Phase I Study of Hydroxyurea in HIV-Infected Children Receiving Didanosine (ddI) and/or Stavudine (d4T)

...Medicine, evaluated the safety, antiviral and immunologic effects, and pharmacokinetics of hydroxyurea, given with ddI and/or d4T to symptomatic HIV-infected children. It is among the first to look at the use of HU in children. The children... Read more »
The Body PRO

Session 84, Abstract 664: Therapy with d4T plus 3TC Produces Sustained Undetectable Levels of Plasma HIV RNA in Patients Treated with Reverse Transcriptase (RT) Inhibitors for 10 Years

...time they sequentially received AZT monotherapy (mean duration of 83 months), AZT + ddI (mean period of 12 months), high-dose d4T "pulse therapy" (for a mean duration of 48 weeks), and, most recently, d4T plus 3TC. Prior to receipt of d4T plus... Read more »
The Body PRO

Abstract No. 398: Treatment with d4T + ddI + Nelfinavir + Hydroxyurea for Early or Recent Primary HIV Infection

...Researchers from UCSF presented data from a study designed to assess the efficacy of a four-drug combination -- ddI/d4T/nelfinavir/hydroxyurea -- for patients with "early" HIV infection (defined as asymptomatic patients with a T-cell, or CD4,... Read more »
Connect With Others


Posted by Survivor, 1 Reply
... Suprunenko: AZT [zidovudine, Retrovir], 3TC [lamivudine, Epivir] and efavirenz [Sustiva, Stocrin]. [Lavra also provides d4T (stavudine, Zerit), ddI (didanosine, Videx), nevirapine (Viramune), nelfinavir (Viracept) and lopinavir/ritonavir... Read more »

Bristol Myers Squibbs: Videx

Posted by Anonymous, 2 Replies
Gentlemen, Stay away from Videx it infected my pancreas and made me diabetic, apprantly it does that to a high percentage of people on it or as I also understand kills another hign percentage of them. What does Bristol Myers Squibbs do? Sell death... Read more »

What is longest period of time HIV+ without...

Posted by Anonymous, 5 Replies
......progression to AIDS? Read more »


Posted by Anonymous, 1 Reply
...called nucleoside analogs, include * AZT (Azidothymidine) * ddC (zalcitabine) * ddI (dideoxyinosine) * d4T (stavudine) * 3TC (lamivudine) * Abacavir (ziagen) * Tenofovir (viread) * Emtriva (emtricitabine) Health... Read more »