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Common Lipodystrophy Symptoms

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AIDS InfoNet

Body Shape Changes (Lipodystrophy)

No researcher has suggested that people with lipo should stop taking ART. What Causes Lipo? We do not know what causes lipo. There are different causes for fat loss and fat gain. Fat Loss Zidovudine (Retrovir, AZT) and stavudine (Zerit, d4T) are linked to fat loss. Efavirenz (Sustiva) may also contribute. Fat Gain One theory is that protease inhibitors interfere with the body's processing of fat. However, some patients who have never...
Ask the Experts

Lipodystrophy Burn

Dr., I am HIV Negative, however, my wbc is a bit low. I have chronic fatigue. My blood sugar and cholesterol levels are normal. I have fat deposits in many places in my body including my face, yet I am generally very thin. I have two questions. 1)...
Douglas T. Dieterich, M.D.

Response from Douglas T. Dieterich, M.D.

New York University, School of Medicine
There are other diseases of mitochondria, like Madelung's disease that can cause lipodystrophy-like symptoms. I have never heard of neuropathy of the fat-affected areas, but neuropathy is common. Ask your MD about other mitochondrial diseases,... Read more »

Protease-Type Lipodystrophy and Bromocriptine(Parlodel)

Dear Doctor,I am a PWA living in Albuquerque. New Mexico with other neurological pre-HIV disabilities that are just now being treated with bromocriptine(Parlodel). During my internet research on this medication, biased, perhaps, by a professional...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Thank you for your interesting comments. I am not aware of any good data regarding bromocriptine and fat redistribution syndrome. Bromocriptine use has numerous potential side effects and it is metabolized in the liver so I would be concerned... Read more »

I wonder about Lipodystrophy

I wonder, If loosing weight is one of the first symptoms, it should be caused by the lypodystrophy so 1- Why is the lipodystrophy just related with medicins1- could to put on weight with a big belly be a symtom of infection or does it appear just...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Liposytrophy is not just related to HIV medications. It is associated with other factors such as age, race, degree of immune damage (higher rates if CD4 count goes lower), and other factors (including possibly genetic difference in individual... Read more »

hypercortisolism and lipodystrophy

I think many of us are frustrated by the slow pace of answers for the problem of lipodystrophy. Time and again we read that there are many questions and few answers. In particular, I'm frustrated by the apparent inattention paid to the theory...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The data is mixed on that but good groups have also reported little association between altered cortisol levels and the manifestations of lipidystrophy/HIV related metabolic disturbances. Another theory is that altered insulin function is a common... Read more »
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exercise and PI lipodystrophy

Posted by Anonymous, 3 Replies
i have been on zerit, epivir and crix for more than one year.
i have lipodystrophy (no more buttocks, fat loss in face and a paunch). I have always been an avid exerciser -- my doc has told me to STOP exercising, that it worsens the situation.
i... Read more »