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Clinical Aids Manifestation Concentration Of Cd4

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Get the Facts
U.S. National Institute of Allergy and Infectious Diseases

The Evidence That HIV Causes AIDS

...recognized in 1981 and has since become a major worldwide pandemic. AIDS is caused by the human immunodeficiency virus (HIV). By leading to the destruction and/or functional impairment of cells of the immune system, notably CD4+ T cells, HIV progressively destroys the body's ability to fight infections and certain cancers. An HIV-infected person is diagnosed with AIDS when his or her immune system is seriously compromised and manifestations...
Ask the Experts

Psycological response to longterm HIV diagnosis?

I read a most interesting and self confirming article in the May/June Issue of PA (Positively Aware) magazine. It was titled, "Is it all in your head?" Since I have been diagnosed now being over 16 years, I have been finding myself depressed, mood...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...surface receptor to enter cells. In the brain, the primary targets of HIV -- monocytes, macrophages, and microglia -- lack the CD4 receptor.Studies suggest that HIV variants that use the CCR5 coreceptor (so-called macrophage- or M-tropic strains)... Read more »

Stepped on a Needle on A Beach and Get Infected

Dear Dr. Bob,I am 64, married, and have been positive for over 14 years. I was infected in a most bizarre fashion....I stepped on a hypo needle on a Florida beach. I started on Crixivan and Combivir 13 years ago, and am still on them. CD4 is 1300...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hi,Contracting HIV from stepping on a discarded hypodermic needle is indeed a very rare occurrence. With your normal CD4 count and undetectable viral load, one wonders if indeed you are really HIV infected. Was your initial test ever reconfirmed Read more »

CNS penetration of Atripla/Ziagen/Isentress

AIDS patients need CNS penetrating anti-vral drugs, right Dr.? In order to bettter fight dementia, memory loss, etc., right? so, how do isentress, Ziagen and 3-in-1 Atripla stack up? Thanz!
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...(T-lymphocytetropic or T-tropic strains). Furthermore, "neurotropic" HIV variants that have evolved the ability to enter cells without CD4 receptors and preferentially target the types of monocytes and macrophages found in the brain appear to... Read more »

Atripla and CNS penetration

Greetings from Charleston, SC! I'm a bit confused by your recent answer to the Florida gentleman who inquired about CNS penetration. If Atripla is only "moderately" effective in penetrating the CNS, shouldn't those of us currently taking Atripla...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...surface receptor to enter cells. In the brain, the primary targets of HIV -- monocytes, macrophages, and microglia -- lack the CD4 receptor.Studies suggest that HIV variants that use the CCR5 coreceptor (so-called macrophage- or M-tropic strains)... Read more »
Articles
U.S. National Institute of Allergy and Infectious Diseases

How HIV Causes AIDS

...Untreated HIV disease is characterized by a gradual deterioration of immune function. Most notably, crucial immune cells called CD4 positive (CD4+) T cells are disabled and killed during the typical course of infection. These cells, sometimes... Read more »
The Well Project

Understanding CD4 Cells and CD4 Cell Tests

... The Basics CD4 Count and HIV CD4 Count and HIV Treatment CD4 Cell Test The Bottom Line The Basics Your immune system protects Read more »
San Francisco AIDS Foundation

Inflammation, Immune Activation and HIV

...act as cell surface receptors or ligands (molecules that bind to receptors), often triggering signaling cascades. HIV uses the CD4 receptor as a gateway to enter helper T-cells, macrophages, and dendritic cells. CD markers also indicate the... Read more »
AIDS InfoNet

CD4 Cell Tests

... What Are CD4 Cells? Why Are CD4 Cells Important in HIV? What Is a CD4 Test? What Factors Influence a CD4 Cell Count? How Are the Test Read more »
Connect With Others

Just Diagnosed With a CD4 Count of 5

Posted by thespoonybard, 1 Reply
...to admit me to ICU. On January 25th, 2009 I was diagnosed as HIV positive and classified an AIDS patient. They told me my CD4 count was 5. I was floored. It felt like my mind was trying to escape from my body to run away from this. Even... Read more »

REVIVO

Posted by Anonymous, 5 Replies
...of desperation when i was diagnosed back in July 2003 and took it (am treatment naive). My VL dropped from 20000 to 3000 and CD4 from 393 to 600 in six weeks! My doctor said it could have been a result of the end of the acute phase of infection.... Read more »

Infectious or Intoxication Diseases?

Posted by Anonymous
...lifelong antiviral treatment, or we treat them usually without any clinical illness, only on the basis of surrogate markers like CD4-cells and viral load, which (latter) can be measured via PCR (the method invented by Kary Mullis). Mullis on his... Read more »

hic

Posted by Anonymous
...infection (days to weeks after exposure) may show lymphopenia and thrombocytopenia, but atypical lymphocytes are infrequent. The CD4 count usually remains normal. The HIV-1 antibody tests (ELISA and Western blot test), the only tests officially... Read more »