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Cd4 Structure

Here's a taste of what has to offer on this topic:
Get the Facts
San Francisco AIDS Foundation

How HIV Damages the Immune System

...single strand of genetic material, while the latter is a double strand ( Figure 3 ). This difference is crucial in the process of T cell infection by HIV. One important feature in the T cell's structure is the CD4 receptor site ( Figure 2 ). CD4 is a protein on the surface of the T cell. HIV's gp120 antigen is a mirror image of the CD4 protein. If HIV bumps into the right place on the T cell's surface, the gp120 of the virus...
Ask the Experts

re structured break

I am confused now. Everything I've read in the forums suggest that drug holidays are a bad idea. How is this case different? How long would someone expect to stay off drugs? Is a drug holiday OK as long as your CD4 counts stay in the thousands? If...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...difficult to answer because the consequences of interrupting HIV treatment are potentially quite different for someone with a 100 CD4 cell count and multidrug resistant HIV versus someone with a 700 CD4 cell count who started with a CD4 count of... Read more »

t4 receptors

Since t4 cells have receptors that hiv binds what does hiv have that causes this binding? Can any part of hiv surface bind to a t4 receptor? Is this binding process purely a chemical reaction? I have noticed over the last ten years when my lipids...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Great questions. HIV has a very specific genetic sequence (and therefore structure) of its envelop protein that binds to the CD4 receptor in a tight lock-and-key way. The relationship between your lipids and HIV viral load is not directly related... Read more »

CD4%, Herpes and Progression

You answered a question of mine some time ago and I thank you for that. Now I have a few more; I contracted HIV in February 1999 and was diagnosed in April 1999. My numbers pre treatment were CD4 330, VL 500,000 and percentage 35%. I have been...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Other ongoing infections like herpes can certainly affect CD4 count and percentage. It is more likely to happen when people are not taking HIV meds than when they are. It would be unlikely Read more »

How many structured interruptions possible?

Dear Doctor,After a four-year break I have now to restart treatment: no big shock, I was prepared to the idea and, on the whole, even surprised that I had been able to live without medications for such a long time (restart is not due to any...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...complications and death, there is still ongoing interest and research in this field. We know that some patients with higher CD4+ lymphocyte counts do fine for periods of time off therapy. An ongoing challenge is determining how to best target... Read more »
The Body PRO

Structured Treatment Interruptions Successful With Patients Who Have High CD4 Counts

...Structured treatment interruption (STI) studies are extremely popular in present-day HIV research. There are a variety of reasons for this Read more »
U.S. National Institute of Allergy and Infectious Diseases

Crystal Structure of Key HIV Protein Reveals New Prevention, Treatment Targets

...thus invisible to the immune system. A ball-and-socket interaction: a residue of phenylalanine 43 that sticks out from CD4 receptors and fits into a hole on the surface of gp120. This phenylalanine "stick" could be a focus for drugs to... Read more »
U.S. National Institute of Allergy and Infectious Diseases

Scientists Unveil Piece of HIV Protein That May Be Key to AIDS Vaccine Development

...gp120. Nature DOI: 10.1038/Nature05580 (2007). PD Kwong et al. Structure of an HIV gp120 envelope glycoprotein in complex with CD4 receptor and a neutralizing human antibody. Nature 393:648-59 (1998). Vaccine Research Center Structural... Read more »
AIDS InfoNet

Treatment Interruptions

...Researchers have studied interruptions of antiretroviral therapy for various reasons. These treatment interruptions are usually called structured or strategic treatment interruptions (STIs), or structured intermittent therapy (SIT). During most... Read more »
Connect With Others

Estoy aterrado cd4/cd8<1

Posted by Anonymous, 7 Replies
...Ayer me dieron una tragica noticia, me hice por si acaso para ver como estaba mi sistema inmune cd4 y cd8 antes de hacerme el elisa , y me dieron un tragica noticia tengo cd4=577 y cd8=779 cd4/cd8=0.74 una persona sana debe tener Read more »

50% of HIV+ Develop Neurocognitive Impairment

Posted by ScotCharles, 3 Replies
...are under "neurocognitive." In addition, a subset of these patients received brain-imaging studies, including studies of the structure of their brains and whether there might be the presence of abnormal signals in the brain. It was found that... Read more »

New to meds

Posted by Brookesta, 2 Replies
I've been diagnosed for 8 years now and managed to deal with what that meant for me and the people closest to me, but I started ART 8 weeks ago and have really struggled, physically (with side effects) and emotionally. I didn't expect this ride to... Read more »


Posted by Bhammer40, 2 Replies
...undetectable naturally without medication. Not really sure what this means since my partners VL count is still in the 70,000s. My CD4 count dropped just a bit too about 749, but my research nurse said that this is still great. Anyhow, I was... Read more »