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Cd4 And Cd8 Lymphocytes In Aids

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Get the Facts
AIDS InfoNet

CD4 Cell Tests

... What Are CD4 Cells? Why Are CD4 Cells Important in HIV? What Is a CD4 Test? What Factors Influence a CD4 Cell Count? How Are the Test Results Reported? What Do the Numbers Mean? "Non-AIDS" Illness and Death The Bottom Line
Ask the Experts

Role of CD8 in HIV progression

Hi Dr. Hope you can help me understand something, in one of your recent posting 15th Feb 2009 you mentioned that - a normal reaction to HIV infection is an increase in CD8 count and percent and that the total lymphocyte count increase is likely a...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...the availability of current potent HIV medication regimens we have today and a better understanding of the functional role of CD8 cells on containing HIV infection. Read more »

Pathology report interpretation

HiPlease interpret this for me...is it looking good or bad?CD4 Lymphocytes Abs - 139CD4 Lymphocytes % - 13CD8 Lymphocytes Abs - 623CD8 Lymphocytes % - 59CD4/CD8 Ratio - 0.22HIV Viarl Load - 28361Viral Load Log value 4.45
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Because the CD4 count is < 200 and the CD4% is < 14%, this indicates an AIDS diagnosis, and you are at risk for developing serious opportunistic Read more »

CD4 high CD8 high total lymphocytes high

Hi Doctor,I just got my CD4/CD8 and FBC labs and they are as follow:1) FCBAll parameters are within the standard range, in the exception of the total lymphocyte count which is of 5.2 billion (std range 1-4)2) My CD4 is 802 but 16.8% and my CD8 is...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Your CD8 increase is a natural reaction to HIV infection. No, I would not recommend starting HAART. Read more »

variance in absolute lymphocytes ?

Dr Mark,If the absolute lymphocytes include both CD4s and CD8s, with the body producing far more CD8s to respond to the hiv infection, then the proportional decline in CD4s, do the absolute lymphocyte counts and percentages go up at infection and...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Total lymphocytes also include B cells. They encompass about 20-25% of lymphocytes. Otherwise your statement is basically correct. Read more »
Articles
U.S. National Institute of Allergy and Infectious Diseases

The Role of CD8+ Lymphocytes in the Control of SIV Viremia

...al. depleted CD8+ cells prior to or during early SHIV infection ( 4 ) . They found ensuing viral loads to be higher while CD4+ cells were lower than controls, suggesting a role for CD8+ cells in clearance of viremia. However, the CD8+ cells... Read more »
Treatment Action Group

Dendritic Cells in Drag: Inauspicious Debut for HIV Specific CTLs; New Concerns about IL-12; Neutralizing Approaches for "Bad" Cytokines; Parke-Davis Targets Cellular Factors

...and act like DC. In vitro, these calcium-ionophore treated cells have been found to effectively present HIV antigens to both CD4+ and CD8+ T-cells. Theoretically, it is possible that if the same effects could be achieved in a person, the T-cell... Read more »
Gay Men's Health Crisis

Stalking HIV Immune Dysregulation

...Viral proteins vpr, tat and nef have been implicated (though vpr may also inhibit apoptosis), as has the binding of gp120 to the CD4 receptors of uninfected cells. HIV protease may play a role in apoptosis of infected cells, perhaps by increasing... Read more »
Canadian AIDS Treatment Information Exchange

The Immune System

...functions, depending on their type. The different T cells can be identified by proteins, called receptors, on their surfaces. CD4+ cells are T cells that have a protein called CD4 on their surface (also referred to as CD4 positive or helper T... Read more »
Connect With Others

First Numbers: Kind of weird

Posted by personpitch, 6 Replies
...quite what I expected. I was hoping I could go a few years without medication, but that doesn't seem to be the case. vl:1000 cd4: 209 So, my VL is relatively low, but my cd4 is just hovering above diagnosable AIDS. The Doctor was a bit... Read more »

Lab Blip?

Posted by jemcd793, 4 Replies
In the past 16 months my T-cell count has declined from 625 to 361 (361 t-cells as of December). I went back for follow-up labwork to confirm the 361 count and my t-cells have went up to 425. I am not currently on meds. My t-cell percentage has... Read more »

Newly Infected and Got Numbers---COnfused?

Posted by pozboy2009, 1 Reply
...what numbers are important (well i do but i can't tell which ones they are from the report). absolute lymphocytes is 3856 my cd4% is 31% and my cd4 absolute is 1211. IO also have an RNA number for the HIV-1 is is about 7000 Read more »

got labs..................

Posted by daisey6205, 3 Replies
...still undetectable viral load and cd4 count 800. my WBC is 4.0 the normal is 4.8-10.8. my cd8 absolute is dropping last test was 588 this one 493, the normal is 300-900. Read more »