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Ccr-5 Gene And Hiv

Here's a taste of what has to offer on this topic:
Henry J. Kaiser Family Foundation

Gene Technique That Alters CCR5-Producing Gene Increases Resistance to HIV in Mice, Study Finds

Altering the gene that produces CCR5 protein on the surface of immune cells using a harmless virus was found to significantly increase resistance to HIV in mice, according to a study published Sunday in the journal Nature Biotechnology , the Press... Read more »
HIV i-Base

Updates on SB728-T, a CCR5-Targeting Gene Therapy

Recently there have been two widely publicised updates relating to SB728-T, a gene therapy for HIV infection developed by Sangamo BioSciences. On Wednesday March 5th the New England Journal of Medicine ( NEJM ) published results from a phase I... Read more »

Genetically Engineered, HIV-Resistant Cells: The Latest Breakthrough in HIV Gene Therapy

A new gene therapy could make a person's CD4+ cells resistant to HIV -- a method that, if successful, would eliminate the need for antiretroviral drugs for those living with HIV, according to a new study conducted by researchers at the Stanford... Read more »
Ask the Experts

CCR5 Delta 032 (Gene Mutation)

Dr Holodniy, I am a Hiv+ female since 2/96. My first Hiv test was done in August 1999, again in September and in November(all in 1999). Each time my vl=undetected T-cells were 1200. In February of this year(2000)I was tested againand my results were...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Thanks for the kudos. HIV requires the CD4 receptor and other "coreceptors" to gain entrance to cells and result in infection. One of these coreceptors is called CCR5. It has recently been discovered that a 32 base deletion (32 delta) in... Read more »

mutated CCR5 gene, delta 32,

Hi, I just finished watching the PBS program on the black plague amd the mutated CCR5 gene, delta 32. They stated in the program the those individuals having two copies of the mutated gene could not be infected by the HIV virus. I live in the...
Ryan M. Kull, C.S.W

Response from Ryan M. Kull, C.S.W

Columbia University's Health & Related Services
As far as I know, the general public does not have access to this sort of testing. While the research on the CCR5 mutation is important and quite compelling, it's too early to tell people that they are definitely and always immune to HIV based... Read more »

How can I get a genetic Test to Determine if I am indeed a carrier of the CCr5 Delta32 Gene?

I am of European decent from boh my mother and fathers side of the family, although I have to say I am also partially Hispanic, but mostly Eurasian in decent......
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
You can likely get this through internet providers, by either a blood test or buccal swab (scraping the inside of the mouth for cells).... Read more »

Research in HIV via CCR5 Delta 32

Hello Dr Franscino, I am curious if the following is currently being researched and if so how I could be involved. I know that scientists have recently been able to induce differentiated skin cells into a stem cell-like state using 4 genes and more...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hi Patrick,No, your concept is not currently being studied and consequently no, you can not be involved. Your hypothesis is faulty on many immunological and genetic levels. You'll understand this more completely after you've been through... Read more »
Connect With Others

The ccr5 gene

Posted by johnson147, 1 Reply
on june 15th 2012 I was exposed to the virus had seroconversion symptoms 2 weeks after but yet to test positive 6 months after exposure. Is it possible that I might carry the ccr5 gene in my body and it blocked the virus from really taking its... Read more »

hiv gene therapy

Posted by hopefulone, 2 Replies
hiv gene therapy has been getting a lot of play in the national and international press as of late....i would be interetested in comments on this hope. Read more »

Gene Therapy "Cure" Research from CROI 2011

Posted by bartleby, 1 Reply
The full transcript of the press conference is a little long, but it's really interesting. They talk about modifying stem cells, knocking off the CCR5 receptor, and reinfusing these new HIV-resistant cells them into the body.

Research is still... Read more »

Interesting article about CCR5 and HIV infection.

Posted by Anonymous, 3 Replies

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