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Can You Die From Mitochondrial Toxicity

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AIDS InfoNet

Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...
Ask the Experts

MITOCHONDRIAL TOXICITY

Anti-HIV drug side effects linked to mitochondrial toxicity have been around for years. It is obvious with the growing incidence and possible role of lipodystrophy. It's a fact that all nukes inhibit cellular DNA polymerase beta and gamma, thus...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
This rather a long question so I hope I can respond to all of it.The risk factors for lipoatrophy inlcude disease characteristics (AIDS, low CD4), genetic characteristics (genes which promote the pro-inflammatory cytokine TNF) and both nucs and PIs.... Read more »

Carnitine and Riboflavin to combat mitochondrial toxicity

Are you using carnitine and riboflavin routinely to try to overcome the possible mitochondrial toxicity that hypothetically may contribute to lipodystrophy? If so, what doses of each are you using?...
Alvan Fisher, M.D.

Response from Alvan Fisher, M.D.

Brown University School of Medicine
No, not routinely.Alvan Fisher, M.D.... Read more »

mitochondrial toxicity

I've been hearing a lot lately about mitochondrial toxicity and I know one of the most common signs of MT is muscle weakness. I'm 52 and have been positive for around 10 years. My viral load is 15,000 and my t-cell count 450. I'm not...
Thomas N. Kakuda, Pharm.D.

Response from Thomas N. Kakuda, Pharm.D.

University of Minnesota
Gary,Dysfunctional mitochondria in the muscles can lead to a condition known as "mitochondrial myopathy" which manifests itself as muscle weakness and fatigue. The famous cyclist Greg LeMond retired in 1994 due to this disease.... Read more »

mitochondrial toxicity

Which drugs in the na class(including tenofovir)have the least about of mitochondrial toxcity VS. the most,or are they all pretty much the same?...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for the question. The issue of mitochondrial toxicity has gain a lot of recent attention. It is clear that mitochondrial toxicity is associated with lactic acidosis, pancreatitis, and certain types of muscle injury; there is conjecture... Read more »
Connect With Others

Re: AIDS Denialist David Pasquarelli Dies

Posted by Anonymous, 3 Replies
PaulKing is wrong and has no knowledge of David's health choices.
David did not die of liver failure, or heart failure (as PaulKing has posted elsewhere), and he did not take HAART for many years before he was a dissident.
David died from advancing... Read more »

Tired of condemnation of those dying or have died

Posted by Anonymous
It has taken me five years to finally stand up to anyone who
has said or says "I should be quiet, don't cause a scene, etc."

Well, I'm no longer able to be quiet, sorry if it embarrasses my family and friends, my church, my pastor, my religion,... Read more »

Toxicity: Your Experiences

Posted by Anonymous
Ok.

I recently tested positive and even though my viral load under 2,000 i have a 389 CD4.

I have been investigating epivir/ziagen and viread..they might be available in a new study on a once daily dosing schedule.

My question is, what do u think about... Read more »

Is gay culture toxic?

Posted by Anonymous, 3 Replies
Everywhere you turn you see images of young, clean shaven, hairless, "buffed" boys gracing the gay mags and movies. Who actually looks like most of these people? All we are given to watch on tv is Will and Grace. They represent like 5% of the entire... Read more »