Aptivus And Hiv

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An Overview of Aptivus (Tipranavir)

tip-RAN-na-veer --> Brand Name: Aptivus Other Name(s): TPV Drug Class: Protease Inhibitors Approved Use: Treatment of HIV Infection WARNING: Tipranavir can cause serious, life-threatening side effects. These include liver problems, severe rash, and bleeding in the brain. Stop taking tipranavir (and ritonavir, the anti-HIV medicine always used with tipranavir) and contact your health care provider right away if you have...

Ask the Experts

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain)... Read more »

Aptivus

Doc,I've read a lot about Aptivus being good for people who have had resistance to other drugs. Is it ever used for people just starting treatment? As someone who has recently tested positive I'm weighing all my options.Thanks! Rob...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Aptivus is also known as tipranavir and is a recently approved protease inhibitor that has activity against virus that is multi-drug resistant. It is typically used as part of a salvage regimen for patients that have drug-resistant virus. There are... Read more »

What to do - Aptivus?

Doctor, vircotype phenotpype showed mutations at 41L, 43Q, 118I, 210W, 211K and 215S and said I had susecptibility to all NRTI's, "maximal" to retrovir. No nNRTI mutations. PI mutations at 10I, 13V,, 33F, 46I, 48V, 54T, 71V, 74S,...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. The best answer to your question will depend on some additional information: viral load, CD4 count, previous treatment history, prior resistance tests, and any known antiretroviral medications intolerances. The short... Read more »

RE What to do - Aptivus

Doctor, thank you for your speedy response. To answer your question, I am six years poz. Treatment naive. Last VL's over the past year ranging 250 to now 158. About 8% each time CD4 to CD8. I know I have these NNRTI mutations...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

It is quite unusual, but not unheard of, to have so many resistance mutations in someone who is nave to treatment. But based on the resistance test from your previous <a... Read more »

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Connect With Others

What should I think?

Posted by motherinlaw, 9 Replies

I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother.
My son and daughter-in-law seem not to... Read more »

Just started ARV - Insurance, Drug costs, expenses

Posted by ajhope, 1 Reply

I live in Thailand and found out I am HIV+ a little over a month ago. My CD4 count was 251 and VL 29,000 - I started ARV 2 weeks ago with the following regiments:
Nevirapine 200 mg - once a day
Lamivudine 150 mg - twice a day
Stavudine 30 mg - twice... Read more »

nuevo medicamento par el vih

Posted by Anonymous, 2 Replies

La FDA (la agencia que regula los medicamentos en Estados Unidos) han informado de que pacientes que tomaban el frmaco para el sida Aptivus (tripanavir) han sufrido una hemorragia cerebral y ocho de ellos han fallecido

En los ensayos clinicos con... Read more »

maintaining hope

Posted by breathe, 3 Replies

I have been taking meds for three years now and phenotype and genotype testing have shown i have extreme resistance i think i may have one regiment that may work and it would include fuzeon....im just trying to remember we are not guaranteed any... Read more »

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