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Antiretroviral Treatment Toxicity

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AIDS InfoNet

Mitochondrial Toxicity

Lactic acidosis can be fatal. See your health care provider immediately if you have these symptoms. MT may also cause nerve damage (peripheral neuropathy, see Fact Sheet 555 ). It has been linked to kidney damage and hearing loss. Some researchers believe it might also contribute to fat redistribution (lipodystrophy, see Fact Sheet 553 ) in people taking antiretroviral medications (ARVs). How Do ARVs Cause MT? Mitochondria have an enzyme...
Ask the Experts

Shingles Starting Treatment & Queen Issues (SHINGLES AND HIV, 2009) (WHEN TO START ANTIRETROVIRAL TREATMENT, 2009)

Hi Dr Bob, Three weeks ago I came down with Shingles. A small patch on the back of my neck and a little across my chest all on the left side. I went to my local GP and he gave me Valtrex ( the 7 day shingle pack)Since then the pain has...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
G'day Aussie Drew,Relax mate! Approximately 95% of healthy adults are seropositive for varicella zoster virus (VZV), the virus that causes shingles. Of this 95%, about 5% of healthy adults develop zoster (shingles). The risk for those of us... Read more »

KIDNEY TOXICITY?

I have been on many combinations of HIV drugs since 1989. After years of HAART I have developed CKD at stage 3 and CAD. Recently, I have had to suspend meds on several occasions because I get very ill with symptoms akin to CKD progression. My blood...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello and thanks for posting.<a href="http://myhivclinic.org/renai-impairment" target=_new>Chronic kidney disease (CKD) and renal impairment</a> is an area of concern in the broad subject of <a... Read more »

NRTI toxicity and Hep C

Dear Dr McGovern;Following my recent diagnosis of chronic Hep C, my antiretroviral therapy was changed to allow for the possible initiation of ribavirin + IFN therapy. My biopsy indicated 1+ fibrosis and 2+ inflammation, and after reviewing the...
Barbara McGovern, M.D.

Response from Barbara McGovern, M.D.

Tufts University School of Medicine
When I treat patients for HCV I never combine ribavirin with DDI since this can cause lactic acidosis and pancreatitis. I also try to avoid ribavirin and AZT since the risk of anemia increases. I do agree with discontinuation of the trisivir. In... Read more »

liver toxicity

I have problems of liver toxicity due to my medicationof -azt-crixivan-videx. I amfeeling fine so far but myblood tests shows problems oftoxicity. Is there any treat-ment available to help detoxication? Thank you....
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Liver problems can be due to a variety of causes. Viral hepatitis due to hepatitis B or C may be aggravated by antiretroviral therapy. Treatment for those forms of hepatitis is available. Use of alcohol or high doses of Tylenol (or some other... Read more »
Connect With Others

"Positive living" eclipsed by ARV (Antiretroviral

Posted by bradford, 1 Reply
"Positive living" eclipsed by ARV (Antiretroviral) drive

Originally, it seemingly appeared that anyone infected with HIV would progress to disease and die. This has long since been realized to no longer be true. We have individuals all over the... Read more »

Toxicity: Your Experiences

Posted by Anonymous
Ok.

I recently tested positive and even though my viral load under 2,000 i have a 389 CD4.

I have been investigating epivir/ziagen and viread..they might be available in a new study on a once daily dosing schedule.

My question is, what do u think about... Read more »

Is gay culture toxic?

Posted by Anonymous, 3 Replies
Everywhere you turn you see images of young, clean shaven, hairless, "buffed" boys gracing the gay mags and movies. Who actually looks like most of these people? All we are given to watch on tv is Will and Grace. They represent like 5% of the entire... Read more »

A Toxic Combination

Posted by Choosing2Liv, 9 Replies
If my dilemma was:

- just dealing with the virus; or

- just suffering with the guilt of cheating on my wife; or

- just the feelings of rejections by those who said they loved me; or

- just the constant blaming, belittlement and bursts of rage from my... Read more »