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Antiretroviral Therapy HAART-associated Lipodystrophy

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AIDS InfoNet

Body Shape Changes (Lipodystrophy)

No researcher has suggested that people with lipo should stop taking ART. What Causes Lipo? We do not know what causes lipo. There are different causes for fat loss and fat gain. Fat Loss Zidovudine (Retrovir, AZT) and stavudine (Zerit, d4T) are linked to fat loss. Efavirenz (Sustiva) may also contribute. Fat Gain One theory is that protease inhibitors interfere with the body's processing of fat. However, some patients who have never...
Ask the Experts

Lipodystrophy (LIPODYSTROPHY)

I'm trying to find CURRENT information about lipo treatment options, but everything I find, including on this site, is over 2 years old. Can you point me to anything newer. I've been advanced/full-blown (technically) for 15 years, and...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hi,The best source for current information about lipodystrophy (lipoatrophy and lipohypertrophy) should be your HIV specialist physician. Treatment options depend on your specific case. There is current information on treatment options on this site... Read more »

Lipodystrophy and Hypertention

Keith, why do you write about hypertention not being related to HAART when articles like this are published?Hypertension Is Common Among HIV-Infected Patients with LipodystrophyWESTPORT, CT (Reuters Health) - High blood pressure is a common finding...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The link between lipodystrophy and hypertension is far from established despite some intriguing pilot studies such at the article by Fred Sattler that you quoted. Larger trials have failed to link HIV treatment with hypertension (indinavir most... Read more »

Lipodystrophy

I am a while 31 yrs old male HIV+ since 1995. In 12/1998 at CD4 450 and VL 10.000 I began HAART with Sustiva+DDI+D4T. Since then my CD4 have remain in the 450-480 range and VL undetectable until now. However in the last months I have developed...
Brian Boyle, M.D., J.D.

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College
The data is very unsettled regarding the causes of lipodystrophy. You are correct that there have been several studies indicating that d4T may be a cause of lipodystrophy; however, there have been several studies indicating the contrary as well. The... Read more »

Long Term Anti-Retroviral Therapy

Have there been any studies regarding long term use of anti-retroviral therapy? I have been on the same regimen (Combivir and Sustiva) for almost seven years....
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
We now have information to show that people who experience good levels of virologic suppression shortly after starting HAART will almost always maintain this suppression after 7-8 years. Further, there does not seem to be any long-term toxicity of... Read more »
Connect With Others

"Positive living" eclipsed by ARV (Antiretroviral

Posted by bradford, 1 Reply
"Positive living" eclipsed by ARV (Antiretroviral) drive

Originally, it seemingly appeared that anyone infected with HIV would progress to disease and die. This has long since been realized to no longer be true. We have individuals all over the... Read more »

Personal opinion about HAART Treatment

Posted by TwinsDad, 1 Reply
Hi,

I was recently infected and I was wondering for people that have been using HAART, What is your personal opinion about the treatment? How long do you think that we will have to use it? Please, let me know.

Thank you in advance for all your... Read more »

CDC says HAART is to blaim

Posted by Anonymous, 4 Replies
From 1992 through 2000, we observed a total of 7188
deaths, 4870 (68%) during the pre-HAART period, and 2318 (32%) during the HAART period.

Compared with the pre-HAART period, proportions of deaths with the following conditions Deaths from... Read more »

reversing lipodystrophy....

Posted by Anonymous, 1 Reply
Positive since 2003 full blown aids. Was on Kaletra and combivir. Reached non-detectable, and cd4 rising as expected. Into 3rd year noticing increase in truncal girth. Waist went from 27in. to 32in of hard solid protruding fat. Arms, legs, face... Read more »