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Alleles In Abacavir Hypersensitivity

Here's a taste of what has to offer on this topic:

Can HLA-B*5701 Testing Help Avoid Abacavir Hypersensitivity Reaction?

Retrospective analyses of abacavir (ABC, Ziagen)-treated individuals who have experienced hypersensitivity reaction (HSR) have suggested that the majority of these abacavir-related events, at least in white and Thai persons, occur in the presence of... Read more »
U.S. Food and Drug Administration

Important Safety-Related Label Update for Ziagen (Abacavir Sulfate)

On July 18, 2008, FDA approved changes to the package insert for Ziagen (abacavir sulfate) highlighting information about the association of the HLA-B*5701 allele (a part of a gene) and hypersensitivity reactions (HSR) caused by abacavir-containing... Read more »
AIDS InfoNet

Abacavir (Ziagen)

What Is Abacavir? Who Should Take Abacavir? What About Drug Resistance? How Is Abacavir Taken? What Are the Side Effects? Hypersensitivity Reaction How Does Abacavir React With Other Drugs? What Is Abacavir? Abacavir (Ziagen) is a drug... Read more »
Ask the Experts

HLA B-5701 Allele

I've been positive since 1999, and I learned early on through a clinical study that I have the HLA B-5701 allele. When the test for this became commercially available, my doctor ordered it for me, and the results confirmed that I have this...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
To date the clinical relevance of the HLA B5701 allele as it pertains to antiretroviral therapy is only established for its relationship to risk for abacavir hypersensitivity reaction (use is contraindicated if HLA B5701 positive) and not for any... Read more »

Abacavir Hypersensitivity

Dear Dr. Henry - I've been on cocktails containing abacavir since 1998. The one I'm on now is abacavir, d4t, agenerase and norvir. I started it almost 6 months ago. I must admit that I've taken a couple "drug holidays"...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The risk for abacavir hypersensitivity is low (yet still exists) when abacavir is stopped and started at times when there are no symptoms suggestive of the hypersensitivity reaction. If symptoms clearly worsen with each dose then the drug must be... Read more »

abacavir hypersensitivity

I began my hiv treatment of abacavir, 3tc and efv and by the end of 6 weeks of treatment developed a rash, gastrointestinal problems and severe achiness, my doctor determined I was hypersensitive to the abacavir and discontinued all treatment until...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Hypersensitivity reaction to abacavir generally develops over the first 1-4 weeks of use-unusual to develop after 6 weeks. Generally only occur in persons positive for HLA B5701 gene haplotype (as that checked for). I am not aware of prednisone... Read more »

Abacavir hypersensitivity?

I've been taking Trizivir and Sustiva for 2 weeks now, but a severe measles-like rash has formed all over the body, starting from the face down to the legs. My doctor thinks it could be Sustiva-related, but I'm worried and think that it...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Starting Sustiva and abacavir together at the same time not infrequently leads to your dilemma. The Sustiva rash is usually self-limited. Abacavir hypersensitivity has the following features:fever (greater than 100.9 F or 38.3 C)nausea, vomiting,... Read more »
Connect With Others

Abacavir - Hypersensitivity - EPZICOM

Posted by Survivor, 2 Replies
David, I read your Email and brought the PDF forward. Dr. Ben was very watchful when I initially got started and had follow up calls to me regarding any problems if in deed I was blinded on the Abacavir. Either I am on it and am fine or I am not... Read more »


Posted by Anonymous, 2 Replies
I'm on day 4 of my new combo Abacavir,viramune,viread, epivir and it totally sucks. I feel lousy all of the time. Is this typical when starting this combo? This is my 4th combo since diagnosis...

Read more »

AbacavirLamivudine to treat HIV infection.

Posted by jenniferdraper
AbacavirLamivudine is used to treat HIV infection. This combination medication is used with other medications. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors. Read more »

Aetna & Ziagen aka Abacavir

Posted by wtxgringo, 1 Reply
So now Aetna has switched over to a generic form of Abacavir from the brand name Ziagen and while I've been getting the Rx for over 6 years from Aetna RX Home Delivery, this months refill was cancelled with the note that Abacavir is now a... Read more »