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Ask the Experts

dietary protease vs HIV protease

My mother who is a dietician feels my regimen of Kaletra, Invirase and Truvada is interfering with fat absorption. She feels this is why PI's seem to result in smelly or loose stools. Her solution, dietary enzymes which contain the...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
What you are describing is a combination of enzymes produced by the pancrease to facilitate digestion and absorption of food from the gut. If there is pancreatic insufficiency then those enzymes are given in pill form and that is often helpful. I... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

drug-protease mechanism

What are the key biochemical features of the drug-protein interaction that allows it to function as a protease inhibitor? ...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
They bind to the active site of the protease enzyme so the HIV polyprotein is not allowed to enter the active site and be cut into smaller pieces by the protease.... Read more »

New Protease Inhibitor

Hello doc. Are you aware of a new protease inhibitor from Bristol Myers called BMS-232632? It's supposedly more potent than any known protease inhibitor, but I don't have any information on the current phase it's in......
Andrew T. Pavia, M.D.

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine
BMS-232632 is a new protease inhibitor that is being developed by Bristol Myers Squibb. Luckily, it is about due to get a real name. The studies presented so far have demonstrated that it has a long half life and probably can be used as a once a day... Read more »
Connect With Others

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous, 2 Replies
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »