Stavudine Side Effects

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Stavudine (Zerit)

What Is Stavudine? Stavudine (Zerit) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. The original patent on stavudine has expired. The U.S. Food and Drug Administration (FDA) approved generic forms of stavudine for sale in the U.S. and under PEPFAR (see Fact Sheet 475 ). Stavudine is also known as d4T or didehydro-deoxythymidine. Stavudine is the most commonly used anti-HIV medication...

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Concerns about long time Stavudine use in a child

My son was diagnosed with AIDS in 1/20/04. As of 6/2004, he has been on a regimen of Stavudine, Lamuvidine and Kaletra. I am concerned about the long term effects of Stavudine. Are there better combinations? Are we going to be sorry that he...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

In adults there has been a unmistakable shift away from using stavudine (Zerit) towards tenofovir (Viread). One of the main reasons for this change is that Viread has a better side effect profile and can be given once daily. The changes in... Read more »

Efficacy of com bination of Nevirapine + Stavudine + Lamivudine

Dear Sir,How do you evaluate the following combination generic drug available in India for initiating treatment of HIV patient in terms of efficacy ? Nevirapine + Stavudine + LamivudineIs there any better combination available to initiate...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

I think that this combination will have high efficacy. Before we were able to get tenofovir (Viread), this was the most commonly prescribed combination in our group and we still have many patients on this regimen. We tend to use Viread instead of... Read more »

Pregnant on Stavudine, Lamivudine + Nevarapine

I am HIV+ and 19 weeks pregnant. My CD4 count is 147 and my Physician has prescribed Stavudine 40mg, Lamivudine 150mg and Nevirapine 200mg. I started taking these antiretrovirals for the first time about 16 days ago. I was 16 weeks pregnant...

Response from Katherine Luzuriaga, M.D.

University of Massachusetts, Medical School

Experience with antiretrovirals during pregnancy is growing and thus far none of the agents that you are on have been asssociated with fetal abnormalities. It sounds as if you are tolerating the antiretrovirals and as if you're experiencing... Read more »

resistance to stavudine

Is there any data that explains why some patients experience clinical failure on a regimen containing stavudine if there are no clinically observed codon mutations linked to stavudine resistance? resistance to stavudine Good question and hard to...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Good question and hard to get an answer. A couple of points though. Although we can't seem to find the mutation we believe causes d4T resistance in the test tube in people, we see the cases you describe. This may be related to other mutations that... Read more »

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Articles

An Overview of Zerit (Stavudine, d4T)

STAV-yoo-deen Brand Name: Zerit Other Name(s): BMY-27857, Estavudina, d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Stavudine, also known as Zerit or d4T, is a type of medicine called a nucleoside reverse... Read more »

European Medicines Agency Issues Restricted Indication for d4T (Stavudine)

The European Medicines Agency has completed a review of Zerit as part of the procedure for the renewal of the medicine's marketing authorisation. The Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended that the marketing... Read more »

FDA Approval of Three Generic Stavudine Formulations

On December 29, 2008 FDA granted approval for three generic fomulations of stavudine. Stavudine is a Nucleoside Reverse Transcriptase Inhibitors (NRTI), which helps keep HIV, the virus that causes AIDS, from reproducing. It is intended to be used in... Read more »

La Guía Annual de Medicamentos para el VIH: Zerit (Stavudine, d4T)

Nombre de Marca: Zerit Nombre Común: stavudine o d4T Clase: nucleósido análogo (también llamado inhibidor de la transcriptasa reversa del nucleósido, NRTI, siglas en inglés) Dosis estándar: Una cápsula de... Read more »

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Need Help

Posted by Anonymous, 2 Replies

My friend has taken Stavudine, Lamivudine and Nevirapine for a month. At the end of the month her Doctor found in a Blood test increased SGPT (550 U/L), SGOT (310 U/L) and Alkaline Phosphatase (1080 U/L).
In two days after a repeated test the... Read more »

wasting

Posted by Anonymous, 1 Reply

This wasting issue is certainly confusing. Ive just read an answer where the doctor said that d4t and ddi are associated with this problem, and so Ive heard from some sero+ people. Others say is because of protease inhibitors, and others say is a... Read more »

pregnancy and HIV

Posted by footeard, 1 Reply

Hi, I have been positive since 1987 and my husband is negative. I am 30 years old. We will be trying to concieve and have a baby in July. I am currently on D4T, Viramune and DDI. I was on AZT monotherapy from 92-94 at 300 mg a day so likely am... Read more »

My chin and body are horrid, HELP!

Posted by Jaz, 2 Replies

Anyone have advice to make me feel better. Have been taking d4t and my chin is so large and my face round, my stomach and abdomen getting larger. Feel so depressed. Doc says can't get rid of it. Can't change meds as this the only one I can... Read more »

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