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Saquinavir Facts

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AIDS InfoNet

Saquinavir (Invirase)

... What Is Saquinavir? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Saquinavir? Saquinavir, also called Invirase, is a drug used as part of
Ask the Experts

nelfinavir resistance after saquinavir

I had sent you a message about my husband last week signing it K-please don'tbother to answer it as weknow which drug gave him the rash (the Viracept- he has been restarted on anescalating dose with no rash sofar after a week). I am concerned about...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...were several interesting(and discouraging) reports looking at response to second protease inhibitorsafter the development of saquinavir (Invirase) resistance. In one, patientswho had developed resistance to saquinavir who were switched to... Read more »

saquinavir with abacavir?

I have been on saquinavir, lumivudine, and d4t since diagnosis in 1998 when my T4s were clear down to 35. They have slowly climbed to 300 and my viral load has been undetectable for some time. I eat and exercise quite well but lypoatrophy...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
...I would not have any concern over the saquinavir which is generally a well tolerated drug. There are no interactions between saquinavir and abacavir so there would be no problem Read more »

Viracept/Saquinivir ALWAYS better than justViracept?

Dr. Gallant: In a couple of your answers you've said that Viracept (as well as Ritonivir) greatly strengthens the otherwiseweak Saquinivir against HIV in combo therapy with nukes. My boyfriend just got d4T/3TC +Viracept prescribed to him ashis...
Joel Gallant, M.D.

Response from Joel Gallant, M.D.

Johns Hopkins University, School of Medicine
...Nelfinavir (Viracept) does not "greatly strengthen" saquinavir (the way ritonavir does), but it does modestly enhance saquinavir levels. While with ritonavir you can take reduced doses of Read more »

Nelfinavir -v- Nelfinavir/Saquinavir Combo

I have been on AZT, 3TC and Crixivan since last December and my VL has dropped to (last reading) 175. However, I amseriously considering a switch from Crixivan to Nelfinavir (Viracept) because ofthe friendlier dosing schedule, and removalof the risk...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...There may be a benefit to using saquinavir in addition to nelfinavir, but we really don't know yet. Nelfinavir doesn't increase saquinavir levels as much asritonavir does. Read more »

An Overview of Invirase (Saquinavir mesylate)

... sack-KWIN-uh-vihr MEH-sih-LATE --> Brand Name: Invirase Other Name(s): Ro 31-8959/003 (Saquinavir mesylate), SQV, Saquinavir mesylate, Saquinavir monomethanesulfonate (Saquinavir mesylate) Drug Class: Protease Inhibitors Read more »

Saquinavir (Fortovase, Invirase)

... --> Brand Name: Invirase Clase de medicamento: Inhibidor de la proteasa El mesilato de saquinavir, conocido también como Invirase, y el saquinavir, comercializado antes en los Estados Unidos como Fortovase, pertenecen a la Read more »
InfoRed SIDA

Saquinavir (Invirase)

... ¿Qué Es Saquinavir? ¿Quién Debe Tomarlo? ¿Qué Es la Resistencia a los Medicamentos? ¿Cómo Se Toma Saquinavir? ¿Cuáles Son los Efectos Read more »
The Body PRO

Ritonavir-Saquinavir Combination Therapy in Patients with Advanced HIV Infection

...Conference onRetroviruses and OpportunisticInfections in Washington,D.C. examined the effect of the combination ofritonavirand saquinavir in advanced HIV positive patients. Prior to these studies,the combination of ritonavir and saquinavir had... Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting. I have just spoken to my son again. He was finally able to convince... Read more »


Posted by LostNconfused, 5 Replies
I tested positive 3 days before Christmas and I think I am still numb to the fact. I haven't told any friends or family because I really don't know how and most are judgemental and I'm sure will walk away. But I guess if they do, then I didn't need... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply
...placebo for the first part of the trial. I regained my weight and enrolled in a study of the first protease inhibitor, Invirase (saquinavir). The background drugs in this study were AZT and ddC -- two drugs I had already used. So with Invirase as... Read more »


Posted by Anonymous
...I am on Norvir/Saquinavir. HIV+ since 1990. I have noticed that sometimes I just plain feel like CRAP...a fatigue that resembles the flu. Sometimes lasts Read more »