Reverse Transcriptase Inhibitors

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Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...

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Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function.... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

not copy itself. These drugs are called chain terminators. Drugs like nevirapine (Virammune) or efavirenz (sustiva) are true reverse transcriptase inhibitors in that they block the function of the enzyme, so the DNA chain also cannot be produced.MH... Read more »

Inhibition/Enzymes

Dear Dr H,Thanks very much foe your helpful answers to previous questions. I am on a reverse transcriptase inhibitor (truvada) and integrase inhibitor. My question is, do these two naturally occurring enzymes have any positive effects for the body?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

These are virus specific enzymes that the virus carries with it, so no, they have no specific function in humans and inhibiting them is very specific and does not cause any problems, except for some toxicities that are unrelated to the inhibition of... Read more »

nukes non-nukes and tides

Can you explain, in simple terms, the differences between nukes, non-nukes, and nucleotide reverse transcriptase inhibitors and the mechanisms they use to stop viral replication?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

HIV reverse transcriptase is the viral enzyme that is largely responsible for replication of the viral genes. There are three different classes of medications that inhibit the HIV reverse transcriptase.Nucleoside RT inhibitors (nukes) are the... Read more »

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Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Fusion Inhibitor News?

Posted by Anonymous

Does anyone know if the fusion inhibitor trials (phase III) are going OK, or where to go for an update? Last I heard 700 patients in 100 countries were in the study for T-20(?)
I went to the Trimeris site and didn't see anything new.

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Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

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