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Spotlight Series: HIV Stigma and Discrimination

Reverse Transcriptase Inhibitors

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

... Non-Nucleoside Reverse Transcriptase Inhibitors NNRTIs in Development NNRTIs No Longer in Development Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact...fusion inhibitors Fact Sheet 470 : new classes of antiretroviral drugs Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug...
Ask the Experts

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Read more »

My chances of reshaping my body with hiv?

I've been positive since 1988, presently on kaletra and epzicom. What can I do to lose extra fat? Don't want to look sick but can't be overweight and uncomfortable either
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...that have shown improvement in lipohypertrophy when protease inhibitors (Kaletra in your case) are switched for non-nucleoside reverse transcriptase inhibitors (NNRTIs). If you have been on treatment with this class in the past and have virus... Read more »

Are Ritonvir / Combivir twins?

Read about life threatening danger of Ritonvir + E. What about Combivir + E? Combivir is not the same as Ritonvir is it?
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...Combivir (combination of 2 nucleoside reverse transcriptase inhibitors) is zidovudine (AZT) + lamivudine (3TC) which is different than ritonavir (Norvir) which is a protease inhibitor. KH Read more »


what are the ARV'S made up of and how do you classify them?
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...Currently available antiretroviral (ARV) medications are classified as being nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs) and fusion... Read more »
AIDS InfoNet

Nucleoside Analog Reverse Transcriptase Inhibitors in Development

... Nucleoside Analog Reverse Transcriptase Inhibitors Nucleoside Analogs (Nukes) in Development Nukes No Longer in Development NOTE: Several fact sheets describe drugs that... are being tested against HIV: Fact Sheet 430 :... Read more »
The Body PRO

Pharmacokinetics of MKC-422, One of the Next Non-nucleoside Reverse Transcriptase Inhibitors, Together with ZDV, 3TC, d4T, and ddI metabolized by the cytochrome P450 liver enzyme CYP3A4, the enzyme responsible for metabolizing the other non-nucleoside reverse transcriptase inhibitors as well as the protease inhibitors. Other NNRTIs and protease inhibitors have not been... Read more »
U.S. Centers for Disease Control and Prevention

United Kingdom: "Virological and Immunological Outcomes at 3 Years After Starting Antiretroviral Therapy with Regimens Containing Non-Nucleoside Reverse Transcriptase Inhibitor, Protease Inhibitor, or Both in INITIO: Open-Label Randomized Trial"

...-- a large international randomized trial -- the study authors compared antiretroviral therapy with two nucleoside analogue reverse transcriptase inhibitors (didanosine + stavudine) plus either a non-nucleoside reverse transcriptase inhibitor... Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) Clinical Trials of HIV-1 Protease Inhibitors (Session 41) Immune Reconstitution (Session 45) Treatment of Primary Infection (Session 47)

... Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) START Observational Study: Longitudinal Follow-Up of Virologic and Immunologic Responses in START I and START Read more »
Connect With Others

Lab, med change, confusion

Posted by kaplan08, 2 Replies
Labs of last year have shown a vload range between <400 and 793, with <400 being most recent; CD4 percentage range from 31% to 34%, with 33% being most recent. Taking only Viramune and Combivir -a test has recently shown resistance to... Read more »

DDC Bites the Dust

Posted by Bear60, 1 Reply
...Pharmaceuticals announced that it will be ending the sale and distribution of Hivid (zalcitabine, also known as ddC), a nucleoside reverse transcriptase inhibitor (NRTI) originally approved in 1992. The tablets will not be available in U.S.... Read more »

Should i Start medication???

Posted by coconyc, 3 Replies
Hi im Coco from nyc I though the benefit or getting tested its to find out the virus in a early time so u can get a good treatment that prolong ur life in a better condition, i got my first results a month ago and i got CD4:276 and VL: 3616, so my... Read more »

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies J&J's HIV franchise, which aims to combat HIV drug resistance Prezista will be followed by TMC125, a non-nucleoside reverse transcriptase inhibitor typically used in combination with other drugs expected to be launched in late 2008. That... Read more »