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Raltegravir Dosing

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AIDSinfo

An Overview of Isentress (Raltegravir, MK-0518)

ral-TEG-ra-vir --> Brand Name: Isentress Other Name(s): MK-0518, MK0158, RAL Drug Class: Integrase Inhibitors Raltegravir, also known as Isentress and MK-0518, is a type of medicine called an integrase inhibitor. Integrase inhibitors work by blocking integrase, a protein that HIV needs to insert its viral genetic material into the genetic material of an infected cell. HIV/AIDS-Related Uses Raltegravir was approved by the...
Ask the Experts

Is it time to quit Atripla

I have gained 25 plus pounds in the belly, having vivid to bad dreams; am suffering from depression, and waking up more tired than when I went to bed- 8 hours+ earlier. I have taken trazadone and when I was complaining about depression, was given...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello and thanks for your post from our neighbor state.Your case raises several points.First, some degree of weight gain isn't uncommon when starting HIV medications. Much of this observation comes from initiating treatment in persons with advanced... Read more »

new hiv meds 4 drugs in one pill taken once a day..

Hi Dr Ben,could you please tell me about this new 4 drugs in one pill, once a day... it sounds great.. when will it be out for general use ???thank you so much for your time..tim Gilead aims to start trials in 2009 of a new four-drugs-in-one-pill...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
hi Tim and thanks for your post.The so-called quad pill is indeed in development by Gilead-- it is a combination of the potential new boosting drug (ie, the long awaited replacement for Norvir) with Gilead's new integrase inhibitor and the parts of... Read more »

Reducing Dose Of Truvada?

I am wondering if it's virologically safe to reduce my Truvada dosage to half a tablet daily OR one full tablet every other day to minimize the risk of developing the NRTI associated side effects (mitochondrial toxicity & Kidney/ bone injury) ?I am...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The risk for mitochondrial toxicity is low with Truvada. Truvada has been a highly effective NRTI backbone for HIV treatment partly because of its favorable pharmacokinetic (drug levels due to dose of drug and handling of drug in the body) and... Read more »

isentress or 2 pi?

Do you think a starting regime (without having results of resistance) with isentress plus truvada would be better than truvada plus 2 pi? would it be agressive enough? my VL is 138.000, my cd4 230, so i really need something good and fast to kick...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
In the absence of any resistance a raltegravir based regimen should compare favorably to a protease inhibitor based regime. The PI based regimen would be dosed once daily and has a higher barrier to resistance while the raltegravir generally should... Read more »
Articles
U.S. Food and Drug Administration

HIV/AIDS Update: Traditional Approval of Isentress (raltegravir)

On January 29, 2009, the Food and Drug Administration (FDA) granted traditional approval for Isentress (raltegravir) 400 mg tablets in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-experienced adult... Read more »
AIDS InfoNet

Raltegravir (Isentress)

What Is Raltegravir? Who Should Take It? What About Drug Resistance? How Is Raltegravir Taken? What Are the Side Effects? How Does it React With Other Drugs? The Bottom Line What Is Raltegravir? Raltegravir (Isentress)... Read more »
Canadian AIDS Treatment Information Exchange

Raltegravir vs. Efavirenz -- Four Years Later

Raltegravir, sold as Isentress, is the first of a new class of drugs called integrase inhibitors and is used as part of combination therapy against HIV infection. Although already approved in high-income countries and regions, clinical trials... Read more »
Test Positive Aware Network

Isentress

Common Name: raltegravir (formerly MK-0518) Brand Name: Isentress Class: HIV integrase inhibitor (also called integrase strand transfer inhibitor or INSTI) Standard dose: One 400 mg film-coated tablet twice a day. Can be taken... Read more »
Connect With Others

Those taking, Raltegravir, Truvada & Atazanavir

Posted by sweetvanilla27, 1 Reply
I am wanting to hear from anyone who have experienced taking Raltegravir, Truvada & Atazanavir and how you have got on with the meds? I first started taking meds in May this year I was put on Truvda and Sustiva first, and was taken off them due... Read more »

raltegravir questions please help me out here

Posted by themushroom, 2 Replies
I am currently infected with a virus in the HIV family It is called Xenotropic murine leukemia virus related virus (XMRV) and is responsible for my HIV like illness and symptoms (chronic oral thrush shingles ect) It is a retro virus that... Read more »

Excessive Mastubation

Posted by Anonymous, 5 Replies
Ever since I found out that I'm poz, I've been spending a lot more time mastubating. Is that normal? Or could it be because of the amount of time I've been spending reading posts about sexual issues? Pleasing myself has become an every day thing... Read more »

Two weeks down and a life time to live

Posted by trulife, 2 Replies
Well folks...it's the end of two weeks on Atripla and so far things are going well. Side effects have been limited and are now subsiding. My biggest problem so far is swallowing the pill. I have always had trouble swallowing pills...go figure...a... Read more »