RNA Undetectable Before Antibodies Develop

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Ask the Experts

Undetectable RNA PCR

Hello doctor. Can you tell me if it would be possible to have an undetectable viral load (RNA PCR <400 copies)3 months after possible exposure, if one had experienced ARS within days of exposure, but has still notseroconverted? In other words,...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

It's possible. The natural history after ARS is still evolving. HIV infection is controlled by both cellular immunity (primarily CD4, CD8, dendritic, and macrophage cells) and B cells which produce antibodies. Some people have more efficient... Read more »

Antibody +ve, RNA -ve

I was found to have HIV positive antibodies in May 2010. My last possible exposure was July 2009... Read more »

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C. »

POSITIVE HIV 1 ANTIBODY TEST BUT NO RNA FOUND IN PCR TEST

DEAR Dr.,MY TEST IS POSITIVE FOR HIV 1 ANTIBODY BUT NO RNA FOUND IN PCR TEST (USING REAL TIME PCR... Read more »

Response from Shannon Southall »

Go to Ask the Experts »

Articles

RNA Test to Detect HIV During Acute, Primary Phase Not Widely Used, New York Times Reports

The New York Times on Friday examined an HIV blood test, which seeks out bits of the virus' RNA and can identify infections during the acute or primary phase. Standard rapid tests, which detect HIV antibodies, can provide immediate results but... Read more »

U.S. Centers for Disease Control and Prevention

Anti-HIV Antibodies May Spur AIDS Vaccine Development

According to Barton Haynes, director of the Duke University Human Vaccine Institute at Duke University School of Medicine, Duke researchers may have discovered how to stimulate production of "broadly neutralizing" antibodies, which could lead to the... Read more »

Antibodies Present in Long-Term HIV Survivors Could Contribute to Vaccine Development, Study Says

HIV-positive people who do not develop AIDS and do not require antiretroviral medication could provide insight for new strategies in vaccine development, according to a study published Sunday in the journal Nature , London's Independent ... Read more »

Discovery of Two Antibodies Could Move AIDS Vaccine Development Forward

Scientists from Scripps Research Institute on Thursday announced they have discovered and isolated two antibodies "with the ability to neutralize [or block the action of] many strains of the AIDS virus, a discovery that might help create a... Read more »

Connect With Others

Undetected HIV-1 RNA,PCR at 17 weeks

Posted by roma2010, 2 Replies

hiya all i have the results of my 17 close to 18 weeks results of a PCR RNA for HIV-1 and it was undetected testing was done by COBAS AmpliPrep (Roche Molecular systems) qualification range of this assay is 48 to 10,000.000 copies i also went to a... Read more »

RNA PCR test

Posted by Anonymous, 2 Replies

Can anybody tell me if a RNA PCR qualitative test is reliable ? - I got a negative EIS test at 7 week but my doctor told me that antibodies take time to show up, depending on many factors and that the RNA test is the only reliable one to check for... Read more »

To Zoom42 RNA vs DNA

Posted by Anonymous, 2 Replies

Hi Zoom,

Before I begin, please understand I'm not a doctor or scientist. I'm someone who unfortunately has an
OCD issue with an exposure I had. The good thing about it is, I've spent a lot of time researching
every aspect of testing, from phone... Read more »

JOCKO's TEST - ELIZA NEG ... HIV/RNA - waiting

Posted by Anonymous, 2 Replies

Hello folks ..... I stayed home from work today, hoping to get all of my test results back. My antibody test (at just over 8 weeks) was negative. Unfortunately, the results of the PCR have not come back as of yet. The neg. Eliza at 58 days adds a... Read more »

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