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RNA Undetectable Absence Of Antibodies

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Get the Facts
U.S. National Institute of Allergy and Infectious Diseases

The Evidence That HIV Causes AIDS

...Med 1994;121:886). In addition, through December 1999, the CDC had received reports of 56 health care workers in the United States with documented, occupationally acquired HIV infection, of whom 25 have developed AIDS in the absence of other risk factors. The development of AIDS following known HIV seroconversion also has been repeatedly observed in pediatric and adult blood transfusion cases, in mother-to-child transmission, and in studies...
Ask the Experts

HCV RNA Result

Dr. McGovern,I had a potential HCV exposure and got a negative HepC antibody result 10.5 weeks post-exposure, and a negative HCV RNA 12 weeks after exposure. Am I HCV negative? Conclusively?
Barbara McGovern, M.D.

Response from Barbara McGovern, M.D.

Tufts University School of Medicine
...at six months. However, in patients who have also had RNA testing, the diagnosis can be made much earlier. In your case, the absence of any detectable viremia at 12 weeks is consistent with no infection. I would not test further. Read more »

Viral Load Not Reliable after period of time???

My gynecologists tells me that the PCR RNA is not reliable. Now after having a negative antibody test at 16 wks and a undetectable (<400 copies) at 18 weeks, I am freaking out. He says that the viral load could very well be undetectable at 18 weeks...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...An undetectable viral load in the ABSENCE of antibodies after 4 months of exposure equals NO HIV infection. Read more »

Undetectable

How can one be undetectable and still know they have the HIV virus? I am having a hard time understanding this concept.
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...test. That test measures HIV RNA in the blood plasma. In almost all HIV infected people, the viral load is detectable in the absence of treatment. It becomes undetectable with treatment. People will still have a positive antibody test and will... Read more »

Undetectable RNA PCR

Hello doctor. Can you tell me if it would be possible to have an undetectable viral load (RNA PCR <400 copies)3 months after possible exposure, if one had experienced ARS within days of exposure, but has still notseroconverted? In other words, could...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...might slow the development of antibodies. If prior viral loads were not obtained to demonstrate a detectable viral load in the absence of antibodies, one always has to consider that HIV infection is not present. If the person has documented HIV... Read more »
Articles
New York State Department of Health AIDS Institute

Diagnostic, Monitoring and Resistance Laboratory Tests for HIV

...antibodies to HIV-1 and HIV-2. Three advantages to these assays are as follows: Collection of the sample is noninvasive The absence of needles increases the safety for the personnel collecting the sample Disposal of potentially infectious... Read more »
The Body PRO

Can HIV be Eradicated?: Report on Dr. David Ho's Presentation

...blunting if not lack of production of gp120 and p24 antibodies as compared to untreated patients. In 7 cases there was also an absence of fresh unstimulated cytotoxic T lymphocyte (CTL) response in their peripheral blood mononuclear cells. Ho... Read more »
U.S. Centers for Disease Control and Prevention

Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

...54,56,69-72 . The second group includes OIs that occur >12 weeks after initiation of ART among patients with suppressed HIV ribonucleic acid (RNA) levels and sustained CD4 + counts >200 cells/ ยต L 73,74 . Determining whether these represent a... Read more »
The Well Project

What Is HIV?

...can also avoid unnecessary worrying. What Tests Are Available? If you have been infected, your immune system will make antibodies against HIV. The most common HIV tests look for these antibodies. The HIV antibody test (called ELISA or EIA)... Read more »
Connect With Others

Accuracy of PCR

Posted by Anonymous, 2 Replies
...as a 6 month ELISA (and certainly a 3 month ELISA). A thought occurred to me...is it possible that one could develop enough antibodies to make the PCR undetectable at 7.5 weeks? The Quest test says it measures down to 10 copies. Do antibodies... Read more »

hic

Posted by Anonymous
...presents with fever of unknown cause. The diagnosis is based on a positive HIV-1 RNA level (more than 50,000 copies per mL) in the absence of a positive enzyme-linked immunosorbent antibody assay (ELISA) and confirmatory Western blot antibody... Read more »

Test results to HIV and HCV

Posted by Anonymous, 2 Replies
...concentration of p24 antigen was 250 ng per liter, the HIV Western blot assay had no positive band, and an enzyme immunoassay for antibodies to HIV was negative. The test for HIV antibodies first became positive on day 31, when the HIV Western... Read more »

elisa vs. pcr

Posted by Anonymous
...Whether extended follow-up is indicated in other circumstances (e.g., exposure to a source coinfected with HIV and HCV in the absence of HCV seroconversion or for exposed persons with a medical history suggesting an impaired ability to develop an... Read more »