PIs And Hiv

Here's a taste of what TheBody.com has to offer on this topic:

Articles

HIV 101: Antiretroviral Agents Dosing and Administration Recommendations: PIs

Adapted from Bartlett J.G. and Gallant J.E. 2001-2002 Medical Management of HIV Infection . Johns Hopkins University, Baltimore, MD. 2001. This table is a replacement for the table that was printed with a copy error on page 8 of the November 2001... Read more »

Use of Pharmacokinetic Enhancement in Antiretroviral Treatment-Experienced HIV Patients

Abstract Protease inhibitors (PIs) are potent agents for controlling HIV infection. The physicochemical properties that make these drugs inherently effective for suppressing intracellular infection also predispose them to the effects of... Read more »

U.S. Centers for Disease Control and Prevention

Response to Newly Prescribed Lipid-Lowering Therapy in Patients With and Without HIV Infection

"Antiretroviral agents, particularly protease inhibitors (PIs), may adversely affect lipid levels in patients with HIV infection. However, it is not known whether HIV-associated dyslipidemia is more difficult to treat," the researchers explained.... Read more »

Ask the Experts

Resitant to all PIs & almost all NRTIs

Hello,I have been HIV+ for 25 years and have done pretty well on my HIV therapies which I began about 17 years ago. Last year my viral load began to increase so my doctor & I decided to switch my regimen. My Pheno & Genotype test showed me...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

You have done well to tell me a great deal about your situation, but I will caution you and other readers of this website that complex cases with high levels of resistance and a long treatment history are the most difficult to summarize accurately,... Read more »

Lypo and PIs

Is there any data on PIs which are the least likely to cause or contribute to lypo? My doctor has prescribed a combo of Norvir/Lexiva/Viread/Combivir. Any suggestions? I am long-term HIV/AIDS with no history of OIs and I have some minor fat loss in...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Our information about the links of specific HIV drugs to various aspects of lipodystrophy is still limited. Non-drug factors may play a major role (age, degree of CD4 drop, time with HIV, sex, race all may influence what happens). Because there... Read more »

Interaction SIMVASTATIN + PIs

Dear Dr YoungI am HIV+ since 2006 ( nadir 104) , CD4 around 650, VL UD,late fifties, and feeling healthy. Current regime Darunavir 800mg+Ritonavir 100mg+Lamivudine300mg once daily ( got rid of Abacavir few months ago ). Despite a sparse and largely...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello Ernest and thanks for posting.Firstly, I'd agree that you should be taking a lipid-lowering medication- if your fasting labs really reveal a LDL of 172, this is a strong indication for the use of a statin medication. Furthermore, if... Read more »

PIs

Can you please confirm what I've heard, which is that PIs grow fat cells in a petri dish. If this is so, what is going on with lipoatrophy and people using PIs.sincerely, thanks.Michael...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

There have been some lab dish type observations involving PIs that suggest they can disrupt fat cell metabolism/activity. Recent data from Barcelona (the FRAN study) suggested that fat loss is the problem most linked to HIV infection and/or... Read more »

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Connect With Others

Drug Resistant HIV

Posted by Anonymous

Hi

I just found out the strain of hiv i have is resistant to possibly a whole class of NRTIs and PIs..any experience with this for any of you? what could the options be for someone in my situation? I am still treatment naive.

Read more »

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