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NNRTI Facts

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AIDS InfoNet

Nevirapine (Viramune)

What Is Nevirapine? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Nevirapine? Nevirapine is a drug used as part of antiretroviral therapy (ART). It is also called Viramune. It is manufactured by Boehringer Ingelheim. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Nevirapine is a non-nucleoside reverse...
Ask the Experts

Resitant to all PIs & almost all NRTIs

Hello,I have been HIV+ for 25 years and have done pretty well on my HIV therapies which I began about 17 years ago. Last year my viral load began to increase so my doctor & I decided to switch my regimen. My Pheno & Genotype test showed me resistant...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
You have done well to tell me a great deal about your situation, but I will caution you and other readers of this website that complex cases with high levels of resistance and a long treatment history are the most difficult to summarize accurately,... Read more »

Kaletra or Sustiva

Thank you Dr Young for you answer. You were asking if the change of med was because of side effects. As you indicated I have terrific immunologic and virologic response, this is why I am not sure why I am switching. The doctor just said before...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your follow up.First off, it's important to recognize that all cholesterol effects are not antiretroviral medication- many people in this country have problems with their cholesterol and don't have HIV, no?So, if the cholesterol is the... Read more »

Concern of NNRTI transmission during chronic infection

(Sorry to resubmit this question Doc, but I mispoke earlier. His doctor recommended taking him off tx. altogether 18 months ago.) Previous - I have a relatively complex question regarding potential reinfection with a NNRTI resistant mutation. I...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
Yes, you should take preventive measures...whatever it will take to discourage you from further doing UAI, which I am guessing stands for unprotected anal intercourse. You obviously know that, but it is the first lesson from this episode, and a... Read more »

The Y181C Mutation

Dear Drs. Is the Y181C mutation that showed up 7 years ago after taken viramune that does not appear on a genotype done today rule out sustiva as a drug option? Thank you.
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your post.In general resistance to one NNRTI [in your case, selected by nevirapine (Viramune) and evidenced by the Y181C mutation] confers resistance to other NNRTIs, like efavirenz (Sustiva). For this reason, if you've had previous... Read more »
Articles
Test Positive Aware Network

Intelence

Common Name: etravirine Brand Name: Intelence Class: non-nucleoside analogs (also called non-nucleoside reverse transcriptase inhibitors, NNRTIs or non-nukes) Standard dose: Two 100 mg tablets twice daily, with food. Take missed... Read more »
AIDS InfoNet

Delavirdine (Rescriptor)

What Is Delavirdine? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Delavirdine? Delavirdine is a drug used as part of antiretroviral therapy... Read more »
AIDS InfoNet

Etravirine (Intelence)

What Is Etravirine? Who Should Take it? What About Drug Resistance? How Is it Taken? What Are the Side Effects? How Does it React With Other Drugs? What Is Etravirine? Etravirine is a drug used as part of antiretroviral therapy... Read more »
AIDS InfoNet

Tenofovir (Viread)

What Is Tenofovir? Who Should Take Tenofovir? What About Drug Resistance? How Is Tenofovir Taken? What Are the Side Effects? How Does Tenofovir React With Other Drugs? What Is Tenofovir? Tenofovir (Viread), also called bis-POC... Read more »
Connect With Others

Lost

Posted by LostNconfused, 5 Replies
I tested positive 3 days before Christmas and I think I am still numb to the fact. I haven't told any friends or family because I really don't know how and most are judgemental and I'm sure will walk away. But I guess if they do, then I didn't need... Read more »

ups and downs

Posted by treading_water, 4 Replies
I tested positive a few months ago during a health check for a work visa. My visa was denied and I was left with no job, a plane ticket home, faced with a lot of concerns, and a lot of questions from friends, family , and co-workers as to what... Read more »

What to do.......?

Posted by Anonymous, 5 Replies
Hi. I have just been diagnosed this week with poor labs - cd4 count - 57, viral load 800,000+. I will commence with Truvada+Sustiva and switch to Atripla as soon as it is approved in England. My question is this - has anyone else been in situation?... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply
Personal Perspective: Resisting Resistance By Matt Sharp Spring 2006 In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not... Read more »