Maraviroc

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Get the Facts

Maraviroc (Selzentry, Celsentri)

What Is Maraviroc? Who Should Take It? What About Drug Resistance? How Is Maraviroc Taken? What Are the Side Effects? How Does It React With OtherDrugs? The Bottom Line What Is Maraviroc? Maraviroc (Selzentry in the US and Celsentri elsewhere) was formerly known as UK 427,857. It is a drug used for antiretroviral therapy. It is manufactured by ViiV Healthcare. Maraviroc is the first "attachment inhibitor" drug. When HIV...

Ask the Experts

Maraviroc

My viral load has become detectable and my doctor would like to put me on Maraviroc and Isentress. I have been reviewing both of these drugs and I have some concerns with Maraviroc. I know it works on the CCR5...seem this drug should be used...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

(or co-) receptor for HIV to enter the T cell. HIV may also use another co-receptor (called CXCR4) to enter the cell. Since maraviroc only blocks virus that use CCR5, it is important to know what type of virus you have before you would use this... Read more »

maraviroc

for cd4 and viral load will be out and i will see an hiv specialist for the drug regimen.i read about new ccr5 inhibitors like maraviroc and it sounds great.i learnt that it stops virus from entering the cells .doctor, can maraviroc or anyother...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

There is comparativey little info about use of CCR5 inhibitors like maraviroc for initial treatment of HIV infection. Since the success rates for initial therapy with current often simple (once daily )... Read more »

Taking Maraviroc

taking crixivan, combivir and bactrim daily..my CD4 around 100 and viral load 6000+my doc suggest me to change my treatment to maraviroc..is it maraviroc suitable for Hep-C/Heamophilia patient with HIV?and what ur suggestion? Taking Maraviroc Thank...

Response from Eric Daar, M.D.

UCLA School of Medicine

given to changing regimens. The best next regimen for you will only be defined by drug resistance testing. It is possible that maraviroc (a newly approved CCR5 antagonist) may be a part of this next regimen. However, you would not know this... Read more »

Atripla and Maraviroc

(my CD4's range between the 400 and 450, CD4/CD8% is 23, VL 16.000).My doc suggested to start with Atripla AND temporarly Maraviroc. He calls it a 'mini trial' as he is curious to see how fast I would become undetectable. After that...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

from a year ago may not accurately reflect the current population of virus in your blood since your virus may evolve to bypass maraviroc by using another receptor. This change can happen even if you are not taking meds. Also, the test to detect... Read more »

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Articles

Once-Daily 150-mg Maraviroc Explored in People Taking Atazanavir/Ritonavir

HIV-positive people taking standard-dose atazanavir/ritonavir plus 150 mg of maraviroc once-daily had lower maraviroc maximum concentrations (Cmax) and average concentrations (Cavg) than HIV-negative people taking 300 mg of maraviroc twice daily... Read more »

Approval of Maraviroc

On August 6, 2007, the Food and Drug Administration (FDA) approved Selzentry (maraviroc) 150 mg and 300 mg tablets, a CCR5 co-receptor antagonist used in combination with other antiretroviral products for the treatment of adults infected with... Read more »

An Overview of Selzentry (Maraviroc, Celsentri)

mah-RAV-er-rock Brand Name: Selzentry Other Name(s): Celsentri, MVC, UK-427,857 Drug Class: Entry and Fusion Inhibitors Maraviroc, also known as Selzentry, is a type of medicine called an entry inhibitor. Entry inhibitors work by... Read more »

Etravirine Lowers Levels of Maraviroc Given at 300 or 600 mg Twice Daily

Etravirine may greatly lower concentrations of maraviroc when the drugs are taken without a ritonavir-boosted protease inhibitor (PI), according to results of a retrospective, multicenter French analysis of antiretroviral-experienced people. 1 ... Read more »

Connect With Others

Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Entry Inhibitors Maraviroc from Pfizer is in Phase II trials and will probably hit the market within a... Read more »

chicago,il. Alguien sabe de alguna cura para vih?

Posted by adriana, 3 Replies

hola, mi nombre es adriana y auque tengo viviendo con el virus 4 anios en realidad no tengo mucha informacion creo q por no querer pensar demaciado en este virus lo hice a un lado, claro sin dejar de cuidarme.
me gustaria saber si alguien de ustedes... Read more »

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