Invirase

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Get the Facts

Invirase

Common Name: saquinavir Brand Name: Invirase Class: HIV protease inhibitor (PI) Standard dose: Two 500 mg film-coated tablets with 100 mg Norvir two times a day with food, or within two hours after a meal. Must be taken with Norvir. Take missed dose as soon as possible, unless it is almost time for your next dose. Do not double up on your next dose. AWP: $996.44 / month for 500 mg tablets Manufacturer contact: Roche...

Ask the Experts

Invirase+

Hello!I have been on medications since 1999, July - Invirase 600 mg tree times daily and Combivir 1 tablet twice daily. My viral load is still below 50 copies, my CD4 cells above 500. My...combination in the so-called "baby-doses" 100 mg...

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

Norvir can give better saquinavir levels and easier dosing, AND we don't know the best dosing regimens. I am surprised you are on invirase alone. Invirase, the hard gel formulation of saquinavir has been replaced by Fortavase, the soft gel, because... Read more »

Invirase and Body Aches

I have been hiv+ for two years and I have recently switched from Fortavse to Invirase. Since the switch I have noticed that I have severe muscle aches and leg cramps. Sometimes I hurt so bad that I can barely get...condition flares up worts, but I...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

whether the problem is muscle or nerve in origin and try to devise a therapy plan. Most patients do as well or better with Invirase as Fortovase (with ritonavir boosting). Peripheral neuropathy can occasionally occur with Invirase yet not seen... Read more »

Invirase-Fortovase

Dear Doctor,I have been on medications since 1999, July - Invirase 600 mg three times daily, Combivir twice daily. My viral load is below 50 copies. Soon I am going to switch to Fortovase. How...doctor even suggests I continue taking Fortovase...

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College

Taking Fortovase as 1200mg thrice daily, 1600mg twice daily or 1000mg twice daily with 100mg Norvir (ritonavir) are roughly equivalent in success rates. I would prefer to start you on one of the twice daily regimens for simplicity and ease of... Read more »

Invirase-Fortovase

Dear Doctors,I have a question concerning my treatment.I have been on Invirase and Combivir since 1999, July. Fortunately my viral load is still below 50 copies. My doctor insists on switching to Fortovase... as a better version of saquinavir. I am...

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

Maria,You definitely should not stay on Invirase, in my opinion. The drug levels of saquinavir are generally so low that resistance is common, and resistance to saquinavir is...(nonnucleoside reverse transcriptase inhibitor) like nevirapine... Read more »

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Articles

La Guía Annual de Medicamentos para el VIH: Invirase (Saquinavir, SQV)

Nombre de Marca: Invirase Nombre Común: saquinavir (SQV) Clase: Inhibidor de proteasa (IP) Dosis estándar: Dos tabletas de 500 mg con 100 mg de Norvir dos veces al día (cada doce horas), con comida o entre dos horas después de una... Read more »

Saquinavir (Fortovase, Invirase)

Brand Name: Invirase Clase de medicamento: Inhibidor de la proteasa El mesilato de saquinavir, conocido también como Invirase, y el saquinavir, comercializado antes en los Estados Unidos como Fortovase, pertenecen a la clase de medicamentos... Read more »

An Overview of Invirase (Saquinavir mesylate)

sack-KWIN-uh-vihr MEH-sih-LATE Brand Name: Invirase Other Name(s): Ro 31-8959/003 (Saquinavir mesylate), SQV, Saquinavir mesylate, Saquinavir monomethanesulfonate (Saquinavir mesylate) Drug Class: Protease Inhibitors Saquinavir... Read more »

Ongoing Safety Review of Invirase (Saquinavir) and Possible Association With Abnormal Heart Rhythms

The Food and Drug Administration (FDA) is reviewing clinical trial data about a potentially serious effect on the heart from the use of Invirase (saquinavir) in combination with Norvir (ritonavir). The data suggest that together the two drugs may... Read more »

Connect With Others

anyone taking Isentress and Invirase combination?

Posted by nevereasy

Isentress is a relatively new therapy. My Dr just added it to my mono therapy of Invirase (boosted with Norvir). I have been undetectable for two years on the Invirase but my Tcells never get over 300. He added Isentress. I have had bad reflux ( not... Read more »

Solution to Atripla Side Effects (at least for me)

Posted by Wiilock, 1 Reply

Hey all, I have been on the "wonder pill" for about 3 years now. Previously was on norvir boosted invirase/truvada combo but the GI problems finally were too much.
Anyway I want to briefly recap what I've learned from some of my homeopathic... Read more »

Liver Function

Posted by NYRN, 1 Reply

I'm taking viread, invirase, didanosine, zidovudine and valtrex and my latest labs indicate high on the liver screens. Has anyone had any liver issues - I don't drink so it's not that! Liver Function Yeah boy am I high on the liver screens.

My... Read more »

PI Monotherapy advice

Posted by logopolis, 2 Replies

Admin OptionsEdit Discussion Close Discussion Edit Your Tags
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Delete Discussion Hi,

My partner has been asked to take part in a clinical trial - Protease Inhibitor monotherapy versus Triple Therapy.

Just gathering some info before he signs up.... Read more »

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