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Interleukin-2 And Immune Function

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Get the Facts
AIDS InfoNet

Immune Restoration

...a patient some immune cells from the patient's twin or an HIV-negative relative. A third method uses cytokines. These are chemical messengers that support the immune response. The most work has been done on interleukin-2 (IL-2), which can lead to large increases in CD4 cells. Unfortunately, this does not lead to better health outcomes. Fact Sheet 482 has more information on IL-2. Another approach is gene therapy. This involves changing...
Ask the Experts

immune based therapies (IMMUNE BASED THERAPIES, 2011)

Happy New Year Dr. Bob,Quick question: what are immune based therapies?Many thanks for your wit and wisdom,Crixus
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...begins reproducing (replicating), which then would allow ART to attack and knock out the infected cells! This has been tried with interleukin-2 and with valproic acid. Unfortunately there are several problems with this seemingly nifty plan.... Read more »

Interleukin-2 "good or bad option"???

First of all, thanks for all your help. Question: I am not on meds yet (CD4 684, CD% 31, VL 1628) but I want to keep my CD4 as high as possible, I read about Interleukin-2 that increase the CD4 with really good results, some of the articles state...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hi,You're back again? And you have a similar question about immune-based therapy for HIV. This time the focus is interleukin-2. IL-2 is perhaps the best studied immune-based therapy. (I did research using IL-2 in HIV-infected patients in the... Read more »

IL-2 & candida

Dear Dr Young,Would you expect interleukine-2 to be of benefit for a case of severe refractory (including amphotericine) candidosis, assuming the CD4 count is about 400 and stable?
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...diagnosis-- there might be a different illness mascarading as Candida.I'm not aware of any information that relates to the effect of IL-2 on Candida in this context-- if your CD4 cell count is 400, I don't think that there would be a tremendous... Read more »

CD4 levels are tanking!

I have been in treatment since 1996. My viral load went undetectable with the additon of protease inhibitors in early '97. For the last few years I have been taking Norvir, Reytaz, and Combvir. All was swell until this year. CD4/% was 1035/35 in...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...but that is little comfort if CD4 count is falling. A full nutrition/hormone and bone marrow assessment is worth discussing. Interleukin-2 has been tried in this setting with disappointing results. There is no effective and safe specific... Read more »
Articles
Project Inform

Interleukin-2 (IL-2, Proleukin) and Immune Function

...IL-2 is an immune-based therapy that results in dramatic increases in CD4 cell counts when used in conjunction with anti-HIV therapy. Read more »
U.S. Centers for Disease Control and Prevention

Research Shows Treating HIV/AIDS With Interleukin-2 Is Ineffective

... Although interleukin-2 (IL-2) in combination with antiretroviral drugs (ARVs) raises CD4+ cell counts more than ARVs alone, it is not clinically beneficial Read more »
The Body PRO

Despite CD4+ Boost, Interleukin-2 Provides No Discernible Long-Term Health Benefits to Patients on HAART, ESPRIT/SILCAAT Studies Find

... The use of interleukin-2 (IL-2) alongside antiretroviral therapy does not further reduce an HIV-infected patient's risk of developing an opportunistic Read more »
The Well Project

Immune Reconstitution

...that our body naturallymakes whenever there is an infection. The most work has been done on a cytokinecalled interleukin-2 (IL-2). To date, trials have shown that IL-2 significantlyincreases CD4 cells in HIV+ people; however the long-term... Read more »
Connect With Others

hiv gene therapy

Posted by hopefulone, 2 Replies
has been getting a lot of play in the national and international press as of late....i would be interetested in comments on this hope. Read more »

PRESENCE OF ANTIBODIES MEANS IMMUNITY

Posted by Anonymous, 1 Reply
...PRESENCE OF ANTIBODIES MEANS IMMUNITY Usually, if you test positive for antibodies that means that your immune system has effectively fought off a pathogen and you now have immunity. But with the HIV test, the logic is reversed. Instead Read more »

Suppressed immune system

Posted by Anonymous, 2 Replies
...Hello, I was just wondering what types of things suppress your immune system, which I know can delay your HIV test from coming up positive? Read more »

HAVE AUTO IMMUNE DISEASE?????

Posted by Anonymous, 2 Replies
...I have read the post "window 1991", if a auto immune disease exists, than the Elisa test could not work at 3 months, is it correct???? Read more »