I Have Hiv Can I Take NNRTIs

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Know Your HIV Drugs: NNRTIs

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs are another class of FDA-approved HIV antiviral drugs. There are currently three drugs approved for use in this class. NNRTIs work by targeting the structure of reverse transcriptase... Read more »

NNRTIs: The Next Generation Approaches

Part I Introduction Mechanisms of NNRTI Activity and HIV NNRTI Resistance NNRTI Resistance in NNRTI-Naive and NNRTI-Experienced Individuals NNRTI Mutations: Resistance and Cross-Resistance NRTI Mutations: The Potential Impact on NNRTIs NNRTI... Read more »

Two New NNRTIs Enter the Pipeline

Data on two novel NNRTIs were presented at today's late-breaker session at the International AIDS Conference in Mexico City. After years with little development for this important class of HIV treatments, news on two somewhat promising compounds is... Read more »

Ask the Experts

Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation at codon 106 in HIV-1 clade C viruses that occurs after exposure to efavirenz appears to result in high-level resistance to other non-nucleotide...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for pointing out the research.So far, this does not seem like a very common issue-- however, a different mutation at codon 103 is commonly found among persons with clade B HIV (the US, Western Europe flavor)- this mutation usually causes high... Read more »

NNRTIs

Are either of the newer NNRTIs, Edurant or Intelence processed differently by the liver than the older drug Viramune? I have been on Viramune for more than 10 years just wondering of switching to one of the newer ones would be considered more...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The major liver concern with nevirapine is early on treatment. After 10 years the rate of liver problems on nevirapine would be expected to be low. Though etravirine and rilpivirine may be viewed as being more liver friendly there is minimal very... Read more »

NNRTIs and lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've been on Sustiva/Truvada for 14 weeks with great results but have been battling high cholesterol for about 10 years, HDL high, LDL low, well controlled...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Lipitor and other statins are not on the absolutely contraindicated list on the FDA approved package insert for sustiva. With anything you just need to be careful and have close followup.... Read more »

HIV-1 and HIV-2 difference

Please what is the difference between HIV-1 and HIV-2. What are the symptoms of each of them.Is ARS the same thing as HIV-1...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

HIV-1 is the predominant form of virus worldwide that accounts for the AIDS pandemic. It was originally derived from a very similar retrovirus in Chimpanzees and made the leap into the human population in Africa in the 1920s as best we can tell from... Read more »

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information

Posted by Anonymous, 1 Reply

Exploring: NIAID, NIH, U.S. DHHS

March 2005
HIV Infection and AIDS: An Overview
INTRODUCTION
AIDS (acquired immunodeficiency syndrome) was first reported in the United States in 1981 and has since become a major worldwide epidemic. AIDS is caused by HIV... Read more »

info

Posted by Anonymous, 1 Reply

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Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

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