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HIV Replication Cycle And Sites Of Drug Activity

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HIV Replication

Hi Dr. Sherer:Does HIV still replicate or mutates even though a person is undetectable?Thank you....
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
Yes. Even in the presence of a viral load below 50 copies/ml, there is evidence of ongoing replication in sequestered sites of HIV infection such as the central nervous system and the gonads. Different viral evolution patterns have been observed in... Read more »

Non CD4 replication

HIV uses CD4 cells to replicate and is blocked by HAART from doing this explaining a VL UD when it's successful. But, is there any replication going on in the non CD4 cells that sequester HIV? like lymphnodes, and other tissues? and if so are...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Great question. First, there are CD4+ t cells and monocytes and other cells with CD4 receptors that exist in lymph nodes and other organs, and are not just circulating in the blood. HIV can infect some of these other types of cells and replicate at... Read more »

Stopping viral load replication

When first diagnosed 3 years ago my viral load was in the hundred thousands, I believe it was 7 hundred thousand. According to this particular strain, I had been infected for 13 years before detection. Immediately started on sustiva and...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
This is a very good question.The best antiretroviral therapy lowers the plasma viral load - which is really a test of the amount of HIV RNA in the blood - by 3-5 logs, i.e. it reduced your viral load from 750,000 to 75,000 (one log) to 7,500 (two... Read more »

Follow-Up on Low Level Viral Replication Issue

Dear Dr. Holodniy:Thanks for your earlier response about my low level viral replication. I took your advice and did nothing, rather than adding another drug to my Atripla regimen, such as Isentress (which would have added toxicity and possibly...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Thanks for the follow-up. yes, I would consider it a blip, given the very low levels of viral load. In many people the viral load level is not zero in the blood. Undetectable means below the threshold of the assay and not zero. There is more... Read more »
Connect With Others

See,I told you HIV replicates a cell's DNA TO RNA

Posted by Anonymous, 1 Reply
The below is plagerized from Gallant ( the guru!)
I know that the present antiretroviral medications do not actually kill the virus.
However, if the medications inhibit the virus from reproducing, doesn't the virus die
by... Read more »

This is the 12 weeks site

Posted by Anonymous, 2 Replies
just a reminder this is the 12 week window site not the 13 week site

Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous, 2 Replies
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »

Beware of scam operators of HIV+ dating sites!

Posted by Anonymous
I have been following the recent revelations of the scandal of match.com and yahoo personals being sued by "paying customers" who allege both these well known and very non HIV+ dating sites were using a very common technique too lure in paying... Read more »