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HIV Integrase Strand Transfer Inhibitors

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Isentress

Brand name: Isentress Generic name: raltegravir, or RAL Class: Integrase inhibitor (integrase strand transfer inhibitor, or INSTI) Manufacturer: Merck and Co., www.isentress.com , (800) 622-4477 AWP: $1,171.31/month Standard Dose: One 400 mg film-coated tablet twice a day, with or without food, with no dietary restrictions. Can be taken by children two years or older. Dosing is based on weight for children 2-11 years old. A new...
Ask the Experts

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

ls isentress integrase inhibitors the future for hiv meds ???

Hi Dr Henry,l have been taking different hiv meds for the past 8 years, and its not much fun with the side effects of the meds, l am reading about isentress integtase inhibitors and would like to know your opinion, is this the new step in hiv...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Raltegravir is a promising new HIV treatment known as an integrase inhibitor. It has mostly been used in patients with resistant virus in complex regimens where it has performed well. It has to be taken twice a day. So far it appears well tolerated... Read more »

Integrase Inhibitor

Dr. Young, I am very interested to hear your thoughts on Integrase Inhibitors. -Do you think they will be successful in developing one? -Do you think it can be potentially used as a monotherapy?-Generally what are your thoughts?...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your questions.Inhibitors of HIV integrase have been under investigation for some time, though none are currently in advanced clinical trials. There have been a couple of aborted candidate compounds, one from Merck, another from... Read more »

New Integrase inhibitor and lipodystrophy risk

There is a once a day integrase inhibitor with a non-PI booster coming up soon, isn't there? What is the integrase inhibitor called and what class does the booster belong to? Setting aside the relative newness of these drugs (and therefore the...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Hello and thanks for posting. The new integrase inhibitor medication is called elvitegravir and the booster is GS 9350. The booster is one of a new class of drugs designed specifically to inhibit the CYP3A liver enzyme system. We already know that... Read more »
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Integrase Inhibitor

Posted by Survivor
I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Today's LA Times Article - Integrase Inhibitors

Posted by Anonymous
Very hopeful! (Despite the sad title.)

http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »

strands

Posted by Anonymous, 1 Reply
how many strands of hiv are there? and does transmission vary ?? for example , is it easier to get a different strand of hiv thru kissing, blowjobs, etc?? just curious. Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »