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HIV Drug Resistance In Naive Patients

Here's a taste of what TheBody.com has to offer on this topic:
Articles
HIV i-Base

Dolutegravir Update: Treatment-Naive and -Experienced Patients and Drug Resistance

Several studies presented new or updated information on dolutegravir. This new integrase inhibitor has potential advantages over raltegravir by being a once rather than twice-daily drug, and over elvitegravir by not requiring PK boosting. Of note,... Read more »
TheBodyPRO.com

Baseline NNRTI Resistance and Virologic Failure in Treatment-Naive Patients on Efavirenz: An Interview With Daniel Kuritzkes, M.D.

Listen (1.9MB MP3, 4.5 min.) Daniel Kuritzkes, M.D., is the director of AIDS Research at Brigham and Women's Hospital in Boston, Mass., and an associate professor of medicine at Harvard Medical School. He presented a study at CROI 2007... Read more »
U.S. Food and Drug Administration

HIV/AIDS Update: Isentress (Raltegravir) Indication Extended for the Treatment of HIV-1 Infection in Treatment-Naive Patients

On July 8, 2009, FDA granted approval to Isentress (raltegravir), for the treatment of HIV-1 infection in treatment-naive patients. The recommended dose for treatment-naive adult patients is Isentress 400 mg twice daily, with or without food. The... Read more »
Ask the Experts

Resistance in Long-Term Treatment Naive Patients

I recently tested positive for HIV, but I know for sure that the infection took place in 1993. My doctor said it is highly unusual for someone to go that long having HIV without getting sick (I am sick now, and have been for about 2 months). I am...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
Everyone with HIV infection in the US, and everyone in a setting where 5% or more of untreated patients have been shown to have acquired a strain of HIV with one or more drug resistance mutations, should have a resistance test before ART is... Read more »

epivir and drug resistance tests unreliable for naive docs

yrs. ago i had a doctor who gave me a pheno-geno type test to see what drugs i was resistant to. Epivir, my favorite HIV drug came out showing i was resistant to it. My doc at that time said Pay no attention to that. It's like being a false...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
The main mutation associated with 3TC resistance (M184V) has some special properties. It alters the activity of the HIV reverse transcriptase making it work somewhat more accurately but slower. Hence viral replication is slowed. It also can restore... Read more »

epivir and drug resistance tests unreliable for naive docs

yrs. ago i had a doctor who gave me a pheno-geno type test to see what drugs i was resistant to. Epivir, my favorite HIV drug came out showing i was resistant to it. My doc at that time said Pay no attention to that. It's like being a false...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
Your confusion, and your doctor's uncertainty, are understandable.The most common cause of 3TC resistance is the M184V mutation. There are some other NRTI mutations that reduce the efficacy of 3TC, like the K65r. However, the M184V is usually... Read more »

treatment naive - multi-drug resistance

Hi. Thanks for the invaluable service you provide to people like me. I've read through many of the Q&A, but I still felt the need to ask the questions myself. I believe I was infected within the last 9 months. My last negative test was...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
You have some time to get the best answers to your questions that you can, and then make the best possible decision. According to current guidelines, you do not require therapy today, i.e. your CD4 cell count is above 350, and your viral load is... Read more »
Connect With Others

Drug Resistant HIV

Posted by Anonymous
Hi

I just found out the strain of hiv i have is resistant to possibly a whole class of NRTIs and PIs..any experience with this for any of you? what could the options be for someone in my situation? I am still treatment naive.

Read more »

New York draws fire over case of drug-resistantHIV

Posted by Anonymous
Nature 433, 788 (24 February 2005)

New York draws fire over case of drug-resistant HIV

ERIKA CHECK

Rare, aggressive form of AIDS used to publicize dangers of unprotected
sex.

[WASHINGTON] A decision by New York health officials to announce the
detection... Read more »

Drug Holidays may be over for HIV patients.

Posted by sunkyst, 3 Replies
Good article on a new study about HIV drug holidays.
http://abcnews.go.com/Health/ReproductiveHealth/story?id=2687714&page=1&CMP=OTC-RSSFeeds0312 Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply
Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »