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AIDS InfoNet

Etravirine (Intelence)

... What Is Etravirine? Who Should Take it? What About Drug Resistance? How Is it Taken? What Are the Side Effects? How Does it React With Other Drugs? What Is Etravirine? Etravirine is a drug used as part of antiretroviral therapy... (ART). It is also called Intelence. It is manufactured by Tibotec Pharmaceuticals. Etravirine is a non-nucleoside reverse transcriptase inhibitor (a "non-nuke" or NNRTI). These drugs stop HIV...
Ask the Experts

Once daily dosing of etravirine (Intelence)?

...I was on Efavirenz and Truvada but recently switched to Etravirine and Truvada because of sleep/dream/emotional issues. I saw some research that suggested the 400 mg dose of Efavirine could be... taken safely once a day...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
There is a study with a new formualtion of Intelence that would be given once a day. We are waiting for final results and then the new form would have to get approval from the FDA. The current pills should not be taken once a day. Stay tuned.Joe Read more »

Changeover to Etravirine

Hi, I am about to change my regime from Truvada and Telzir to Truvada and Intelence. I was told that I can do a straight switch, but I note from the information on Intelence that the Telzir/fosamprenavir should not be taken at the same time. Does...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...Though there is concern about somewhat unpredictable interactions between fosamprenavir and etravirine when used together. For a simple switch from one to another I would be less concerned (I would be concerned if your viral load Read more »

Etravirine (TMC-125) Clinical Trial?

...feelings of low depression. I visited my doctor yesterday and she has recommended that I go on a clinical trial for 6 months with Etravirine (TMC-125. Everything seems to be moving rather fast and I'm unsure what to do next, do you think that...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...Etravirine can be effective after failing efavirenz based therapy depending on the resistance picture. Use of etravirine may be one reasonable Read more »


...positive for almost 8 years now and I have a concern regarding Sustiva (which i have been on since diagnosis). I wanted to know if Etravirine can be used in place of Sustiva (if and when i become resistant to it)? Is this drug only successful...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
...Etravirine, also known affectionately as TMC125, is a non-nucleoside that is in the last stages of development and is expected to be available... in the US within months.Some facts:-Etravirine can be taken with nucleosides.-Some virus that is... Read more »
U.S. Food and Drug Administration

Intelence (Etravirine) Label Revised to Include New Drug-Drug Interaction Information

... FDA recently updated Intelence (etravirine) label to include drug-drug interaction information between etravirine and fluconazole, voriconazole, lopinavir/ritonavir tablets...clopidogrel. The major changes to Section 7 Drug Interactions are... Read more »

An Overview of Intelence (TMC125, Etravirine)

...Other Name(s): ETR, ETV, Etravirina, TMC 125, TMC-125, TMC125 Drug Class: Non-nucleoside Reverse Transcriptase Inhibitors Etravirine, also known as Intelence or TMC125, is a type of medicine called a non-nucleoside reverse transcriptase... Read more »
U.S. Food and Drug Administration

Newly Approved Intelence (Etravirine) Dose May Halve Pill Burden

... On December 22, 2010, the Food and Drug Administration approved a new 200 mg Intelence (etravirine) tablet. Intelence was originally approved in 2008, in only a 100 mg tablet formulation. The new 200 mg dosage form can help Read more »
U.S. Food and Drug Administration

Intelence (Etravirine) Label Updated to Reflect Dosing Data Through 48 Weeks

... On November 24, 2009, FDA approved revisions to the INTELENCE (etravirine) labeling to include updated results through 48 weeks of dosing for the two Phase 3 trials TMC125-C206 and TMC125-C216 in treatment-experienced...digoxin, maraviroc and... Read more »
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Urge segunda opinion

Posted by Edy, 1 Reply
...Didanosine Abacavir Emtricitabine Mi doctora me pinto un panarama muy pesimista y medijo que solo tengo una opcion de esquema: Etravirine+combivir+tenofovir+atazanavir. y que no hay otra opcin. Mi preocupacion mayor es el combivir ya que lo... Read more »

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting. I have just spoken to my son again. He was finally able to convince... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law seem not to... Read more »