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An Overview of Intelence (TMC125, Etravirine)

Brand Name: Intelence Other Name(s): ETR Drug Class: Non-nucleoside Reverse Transcriptase Inhibitors Approved Use: Treatment of HIV Infection WARNING: Etravirine can cause serious, life-threatening side effects. These include severe rash and allergic reactions. Contact your health care provider right away if you have a rash. Stop taking etravirine and contact your health care provider right away if you have a rash along with any...
Ask the Experts


positive for almost 8 years now and I have a concern regarding Sustiva (which i have been on since diagnosis). I wanted to know if Etravirine can be used in place of Sustiva (if and when i become resistant to it)? Is this drug only successful with...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
Etravirine, also known affectionately as TMC125, is a non-nucleoside that is in the last stages of development and is expected to be available... in the US within months.Some facts:-Etravirine can be taken with nucleosides.-Some virus that is... Read more »

Etravirine (TMC-125) Clinical Trial?

feelings of low depression. I visited my doctor yesterday and she has recommended that I go on a clinical trial for 6 months with Etravirine (TMC-125. Everything seems to be moving rather fast and I'm unsure what to do next, do you think...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Etravirine can be effective after failing efavirenz based therapy depending on the resistance picture. Use of etravirine may be one reasonable... Read more »


Hi Dr. Young,Is Etravirine and Nevirapine processed in the same part of the liver? I have been on Nevirapine for 10 years and I amhaving some liver issues.... I wonder if Etravirine would use adifferent part of my liver?thanks,tom...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello Tom and thanks for posting.Both medications are processed by the liver, though one generally doesn't distinguish between different parts or cells in the liver with regard to drug metabolism. That said, drug reactions from one medication... Read more »

How is taken darunavir and etravirine?

Good day, I have a the question about what time is the better to take darunavir/r and etravirine. My doctor told me I have to take them always with food, the instructions say that etravirine is taken after a meal, and darunavir/r...before). I cant...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Hello and thanks for posting.Yes, it is important to be mindful of the best dietary practices when taking HIV medications. In your case, it matters less about exactly when you take the medications with respect to meals; rather, I'd suggest... Read more »
Connect With Others

Urge segunda opinion

Posted by Edy, 1 Reply
El problema es que me hicieron un genotipo y segun el resultado sali resistente a:

Mi doctora me pinto un panarama muy pesimista y medijo que solo tengo una opcion de esquema:... Read more »

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting.

I have just spoken to my son again. He was finally able to convince his... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother.
My son and daughter-in-law seem not to... Read more »