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Efavirenz Side Effects

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AIDS InfoNet

Efavirenz (Sustiva)

What Is Efavirenz? Efavirenz is a drug used as part of antiretroviral therapy (ART). It is also called Sustiva or Stocrin. It is manufactured by Bristol-Myers Squibb. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Efavirenz is a non-nucleoside reverse transcriptase inhibitor (a "non-nuke" or NNRTI). These drugs stop HIV from multiplying by preventing the reverse transcriptase enzyme from working. This enzyme...
Ask the Experts

Length of efavirenz (Sustiva) side effects

I have been on Stocrin (efavirenz, another trade name is Sustiva) for a month and I work mostly at night. Will the side effects of nightmares and me not thinking straight ever stop?...
David Fawcett, Ph.D., L.C.S.W.

Response from David Fawcett, Ph.D., L.C.S.W.

South Florida Center for Counseling and Therapy
The side effects of efavirenz are well-known, and can include nightmares, confusion, abnormal thinking, depression, and even thoughts of suicide. These usually diminish after six to eight weeks. Keep your physician informed and if these side... Read more »

Delayed / Prolonged side effects of efavirenz

Hi Doctor, I started on Truvada and Efavirenz about 5 weeks ago when my CD4 was around 420 (21%) and VL around 20,000. In the first week after I started the medication, I experienced the usual side effects of giddiness, bad moods and the feeling of...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
You are describing what is likely persistent side effects from efavirenz (may be worth checking blood level of efavirenz). Perhaps 5-10% of patients have persistent efavirenz central nervous system problems even after the first 2-4 weeks. When that... Read more »

Efavirenz pychotic side effects

My sister in zambia is on EFV,d4T and 3TC. She is taking ant TB drugs as well- intense phase. Her CD4 count is 33 and has only been on ARVs for 1 week. Before the ARVs she had 2 episodes of convulsions which led to Cryptococcal menigitis being...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Generally a patient can be treated through the early period of brain side effects from efavirenz. Otten some sort of sedative /sleep drug is offered to help out during the first several weeks when a patient is having significant problems. The... Read more »

Efavirenz Side Effects

Dr. Henry,Can one of the side effects of efavirenz be stomach and bowel problems if you eat a few hours before taking the pill?When on HIV meds, is it common after a few years of being on them to experience cramps and stomach pains? I had a...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I have had a few patients who seemed to have stomach/gut problems from efavirenz (Sustiva) though more often it was due to one of the accompanying drugs (most often the AZT in Combivir or less often the tenofovir in Truvada or Atripla). KH... Read more »
Connect With Others

Efavirenz: ways to fight its sleep-reduction.

Posted by BrokenWingedBird, 2 Replies
If Efavirenz (and Efavirenz along)is really wrecking your sleep quality, then the only solution is to stop taking Efavirenz (and substitute it with another drug).

However, there are ways to ensure your sleep is as good as possible.

Important discovery: Read more »

Cost of Combivir (Duovir) and Cost of efavirenz(Sustiva) in Canada

Posted by raj1984, 1 Reply
Hey pals this is urgent , I need to know the cost of Combivir and Sustiva in Ontario (CANADA) . Please quote the price of Brand and not Generic . This is very urgent I am need to submit to immigration lawyer. Read more »

Cost of Combivir (Duovir) and Cost of efavirenz(Sustiva) in Canada

Posted by raj1984
Hey pals this is urgent , I need to know the cost of Combivir and Sustiva in Ontario (CANADA) . Please quote the price of Brand and not Generic . This is very urgent I am need to submit to immigration lawyer. Read more »