Efavirenz Dose

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Articles

Efavirenz Dose Increase to 800 mg QD With Rifampin in Patients >50 kg

On 6 January the FDA approved revisions to the efavirenz (Sustiva) package insert to include dosing with efavirenz and rifampin. The Dosage and Administration and Drug Interaction sections of the package insert were updated to include the following:... Read more »

Population Pharmacokinetics of Efavirenz to Inform Dosing in Children 3 Months of Age and Above

The U.S. FDA recently expanded the indication for efavirenz (EFV) to include children at least three months old based on a population pharmacokinetic (PK) model to assess dosing for this age group. 1 These data were presented at the 14th... Read more »

Lopinavir Troughs Lower in Children on Once-Daily Dose With Efavirenz

Children who switched from twice- to once-daily lopinavir/ritonavir plus efavirenz had a low lopinavir trough concentration in a small Thai study. 1 Troughs were not as low during twice-daily lopinavir/ritonavir dosing with or without efavirenz or... Read more »

Ask the Experts

Atripla+Extra dose of Efavirenz 200 mg

Hi Doc,I live in Australia and been diagnosed with HIV + active TB on January 2011.Now i still on TB medication ( Rifadin + Isoniazid) and for HIV i took Atripla once a day. My VL now 209 and CD4 Count 504.My doctor told me to have extra dose of...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

Dear Ivan,Your doctor is correct in adding the extra 200 mg of efavirenz while you are on TB treatment.This is because the rifadin (rifampin) will cause a DECREASE in the efavirenz level, which is compenated for by the extra 200 mg capsule.Once the... Read more »

I miss my dose of Duovir and Efavirenz

I am taking usually the Duovir and Efavirenz twice a day and last night, I missed my dose and remember in the morning when my next dose is due (only duovir). What should I do? Should I take the efavirenz in the morning or just skip that missed dose?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Missing a single dose of Duovir (AZT/3TC or Combivir in US) while taking efavirenz usually wont result in any problem such as quick development of drug resistance. Though you could take the dose of Duovir the next morning (thus two doses of Duovir... Read more »

Efavirenz making my head spin

I am currently taking Truvada and Efavirenz. I take these pills and 10pm, and thereafter I shower and go to bed. On three occasions I have attempted to go out after taking my meds, by midnight my head starts spinning and I cant make sense of...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Your description of the head spinning sounds like an efavirenz (Sustiva) side effect. Delaying the efavirenz dose until you are safely home and ready for bed is a very reasonable way to manage the situation-I would inform your HIV provider... Read more »

Drug interactions; Efavirenz and rifampicin

I have a patient whose CD4 count was 8 and has Pulmonary Tuberculosis,I have started her on treatment for TB 2EHRZ/6EH and considering to start her on given that she is severely immune suppresed.This regimen is suggested;3TC+D4T+EFVShe is 60kg. My...

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College

The recommended dose of efavirenz in a patient on rifampin is 800mg daily, and that is what I would give.... Read more »

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Efavirenz: ways to fight its sleep-reduction.

Posted by BrokenWingedBird, 2 Replies

If Efavirenz (and Efavirenz along)is really wrecking your sleep quality, then the only solution is to stop taking Efavirenz (and substitute it with another drug).

However, there are ways to ensure your sleep is as good as possible.

Important discovery: Read more »

HALF DOSING MY MEDS

Posted by Anonymous, 1 Reply

Hello All !! I want to tell everyone that I started taking half of the prescribed doses of my meds about 2 years ago. My T cells remain High (570) and my V load is still undetectable..
I am on viramune,ziagen and zerit. I had an uncle who died... Read more »

dosing schedule adjustment

Posted by pozartistsd, 1 Reply

hey all you experts out there! I think i may know the answer to this but would like to get some input:

I currently take my meds (Reyataz/Truvada/Norvir) once a day. I take them at 9am (with breakfast, not that you need to know that

) I would like... Read more »

Low-Dose Naltrexone

Posted by renevatio, 1 Reply

Hello all-

I am newly diagnosed, and just getting into the process of researching all about HIV and potential alternative treatments. I am a voracious reader and spend a good bit of time each day reading papers and digging up info on my new internal... Read more »

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