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Didanosine Facts

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AIDS InfoNet

Didanosine (Videx, ddI)

...Didanosine React With Other Drugs? What Is Didanosine? ddI (Videx) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb and by Barr Laboratories. Didanosine is also known as ddI or dideoxyinosine. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Didanosine is a nucleoside analog reverse transcriptase inhibitor, or nuke. These drugs block the reverse...
Ask the Experts

Vision Changes with Didanosine

My partner had his meds changed two months ago and two weeks ago had a sudden change in vision. He now has to squint to focus day or night and is seemingly more light sensitive than normal. We discussed this with our doctor who said we most likely...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
...prescription lenses can occur quickly at some ages (esp mid-40s). This is a change in lens shape. Reports mostly with high doses of ddI of visual changes were related to retinal (back of the eye) problems and were generally reversible on drug... Read more »

neuropathy pain (didanosine+stavudine+efavirenz)

Dear Dr Robert J. Frascino, I'm sure many patients email you a lot of times regarding this matter. But I really really hope you won't get bored. I'd really really appreciate your help, time and patience!My question is:My father CD4 recently = 480He...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hi Tom,Didanosine (ddI) plus stavudine (d4T) is no longer a recommended combination! It has been found to be less effective and substantially more toxic Read more »

zidovudine, didanosine, kaletra

Is the above combination suitable for one considered to be resistant to combivir and effavirenz? I have come across these in the internet. My doctor thinks I could be resistant to combivir and effavirenz. I have been on them for 2 years. Due to...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,Ideally speaking, if resistance develops to a HAART (highly active antiretroviral therapy) regimen, I recommend getting a resistance test to help guide the choice of the next regimen. If resistance testing is not an option in Zimbabwe and your... Read more »

DIDANOSINE - 3rd time enquiring!

This is my 3rd time asking this forum.Please do let me know if ddI (didanosine) chewable tablets could be taken once daily basis ? My weight is below 60 kg. so could I take 3 tabs at a time?
Judith A. Aberg, M.D.

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine
...answered your first request but I am responding again because you have more information this time regarding your weight. Videx (DDI) needs to dosed according to weight and kidney function. Assuming your kidney function is normal, the dose of DDI... Read more »
Articles
AIDSinfo

An Overview of Videx (Didanosine, ddI)

... Brand Name: Videx EC, Videx Other Name(s): BMY 40900, BRN 3619529, CCRIS 805, Didanosina, Dideoxyinosine, HSDB 6548, ddI Drug Class: Nucleoside Reverse Transcriptase Inhibitors Didanosine, also known as ddI... Read more »
The Body PRO

Abstract No. 402:Phase I/II Dosing Study of Once-Daily Hydroxyurea (HU) Alone vs Didanosine (ddI) Alone vs ddI + HU

...In earlier studies, hydroxyurea, when added to DDI or D4T increased the activity of a single or dual nucleoside therapy by 0.5 to 0.7 log 10 copies/mL. The authors, in this placebo Read more »
The Body PRO

Abstract No. 402: Phase I/II Dosing Study of Once-Daily Hydroxyurea (HU) Alone vs Didanosine (ddI) Alone vs ddI + HU

...a phase I/II, randomized, placebo-controlled five-arm study comparing HU alone at two doses (1000 mg a day and 1500 a day), ddI alone (200 mg twice a day), and ddI/HU in treatment naïve and experienced subjects. The HU groups had ddI added after... Read more »
The Body PRO

Safety and Efficacy of Once-Daily Dose of Didanosine (DDI)

...Dr. E. Martinez and colleagues from Barcelona, Spain, reported on 80patients who received ddI once a day, plus D4T 40 mg bid, with or withoutsaquinavir or indinavir. The mean baseline CD4 count was 178 cells/mm3, andthe Read more »
Connect With Others

Early HIV Treatment Failure Linked to Didanosine/T

Posted by TwinsDad, 1 Reply
...NEW YORK (Reuters Health) Aug 23 - The combination of the antiretroviral agents didanosine, tenofovir, and efavirenz is associated with a high virological failure rate in treatment-naive patients with HIV, British investigators Read more »

50% of HIV+ Develop Neurocognitive Impairment

Posted by ScotCharles, 3 Replies
...remembering, planning, making decisions, attentional abilities, concentration; those kinds of skills are under "neurocognitive." In addition, a subset of these patients received brain-imaging studies, including studies of the structure of their... Read more »

Lost

Posted by LostNconfused, 5 Replies
I tested positive 3 days before Christmas and I think I am still numb to the fact. I haven't told any friends or family because I really don't know how and most are judgemental and I'm sure will walk away. But I guess if they do, then I didn't need... Read more »

Controversial Subject

Posted by pozmarie, 2 Replies
I am a 29 year old woman who has been HIV poz for approx. 10 years. I have a CD4 of approx. 800 with undetectable viral load. I had one daughter young before I contracted HIV and did not get married but remained good friends with her father. Fast... Read more »